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1PAU
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BU of 1pau by Molmil
Crystal structure of the complex of apopain with the tetrapeptide aldehyde inhibitor AC-DEVD-CHO
Descriptor: ACE-ASP-GLU-VAL-ASJ, APOPAIN
Authors:Rotonda, J, Becker, J.W.
Deposit date:1996-06-06
Release date:1997-07-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
Nat.Struct.Biol., 3, 1996
1PYO
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BU of 1pyo by Molmil
Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho
Descriptor: ACETYL-LEU-ASP-GLU-SER-ASJ, Caspase-2
Authors:Schweizer, A, Briand, C, Grutter, M.G.
Deposit date:2003-07-09
Release date:2003-08-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
J.Biol.Chem., 278, 2003
1M72
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BU of 1m72 by Molmil
Crystal Structure of Caspase-1 from Spodoptera frugiperda
Descriptor: 1,2-ETHANEDIOL, Ace-Asp-Glu-Val-Asp-chloromethylketone, Caspase-1
Authors:Forsyth, C.M, Lemongello, D, Friesen, P.D, Fisher, A.J.
Deposit date:2002-07-18
Release date:2004-01-20
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an invertebrate caspase.
J.Biol.Chem., 279, 2004
1QDU
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BU of 1qdu by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK
Descriptor: CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR
Authors:Blanchard, H, Grutter, M.G.
Deposit date:1999-07-10
Release date:2000-07-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Structure Fold.Des., 7, 1999
7WR0
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BU of 7wr0 by Molmil
P32 of caspase-4 C258A mutant
Descriptor: Caspase-4
Authors:Hou, Y.J, Zeng, H, Shao, F, Ding, J.
Deposit date:2022-01-26
Release date:2023-01-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.
Nat.Struct.Mol.Biol., 30, 2023
6BFJ
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BU of 6bfj by Molmil
Caspase-3 Mutant - T245D,S249D
Descriptor: AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-26
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.543 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BG0
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BU of 6bg0 by Molmil
Caspase-3 Mutant - D9A,D28A,S150D
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ...
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-27
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.125 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BFL
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BU of 6bfl by Molmil
Caspase-3 Mutant- D9A,D28A,T245D
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-26
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BFO
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BU of 6bfo by Molmil
Caspase-3 Mutant- T245D
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ...
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-26
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BG4
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BU of 6bg4 by Molmil
Caspase-3 Mutant- T152D
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, CHLORIDE ION, ...
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-27
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BDV
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BU of 6bdv by Molmil
Crystal structure of Caspase 3 S150A
Descriptor: AZIDE ION, Acetyl-Asp-Glu-Val-Asp-CMK, CHLORIDE ION, ...
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-24
Release date:2018-02-14
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.938 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BFK
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BU of 6bfk by Molmil
Caspase-3 Mutant- T245A
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, Caspase-3, SODIUM ION
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-26
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.753 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BG1
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BU of 6bg1 by Molmil
Caspase-3 Mutant - D9A,D28A,S150E
Descriptor: AC-ASP-GLU-VAL-ASP-CMK, Caspase-3, SODIUM ION
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-27
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6BGR
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BU of 6bgr by Molmil
Caspase-3 Mutant - S150E
Descriptor: AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-29
Release date:2018-02-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
1IBC
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BU of 1ibc by Molmil
CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME
Descriptor: INTERLEUKIN-1BETA CONVERTING ENZYME, PEPTIDE ACE-TRP-GLU-HIS-ASA
Authors:Becker, J.W, Rotonda, J.
Deposit date:1997-02-12
Release date:1998-02-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
Chem.Biol., 4, 1997
1ICE
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BU of 1ice by Molmil
STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME
Descriptor: INTERLEUKIN-1 BETA CONVERTING ENZYME, TETRAPEPTIDE ALDEHYDE
Authors:Wilson, K.P, Griffith, J.P, Kim, E.E, Navia, M.A.
Deposit date:1994-09-29
Release date:1995-07-28
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of interleukin-1 beta converting enzyme.
Nature, 370, 1994
3DEH
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BU of 3deh by Molmil
Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor: Caspase-3, isoquinoline-1,3,4(2H)-trione
Authors:Wu, J, Du, J, Li, J, Ding, J.
Deposit date:2008-06-10
Release date:2008-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species
J.Biol.Chem., 283, 2008
3EDR
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BU of 3edr by Molmil
The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO
Descriptor: Caspase-7, Inhibitor Ac-ldesd-cho peptide
Authors:Agniswamy, J.
Deposit date:2008-09-03
Release date:2008-10-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for executioner caspase recognition of P5 position in substrates.
Apoptosis, 13, 2008
3E4C
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BU of 3e4c by Molmil
Procaspase-1 zymogen domain crystal structure
Descriptor: Caspase-1, MAGNESIUM ION
Authors:Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M.
Deposit date:2008-08-11
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
J.Biol.Chem., 284, 2009
3EDQ
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BU of 3edq by Molmil
Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO
Descriptor: AC-LDESD-CHO peptide, Caspase-3
Authors:Fu, G.
Deposit date:2008-09-03
Release date:2008-10-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural basis for executioner caspase recognition of P5 position in substrates.
Apoptosis, 13, 2008
3D6F
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BU of 3d6f by Molmil
Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:2008-05-19
Release date:2010-03-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).
To be Published
3D6M
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BU of 3d6m by Molmil
Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:2008-05-19
Release date:2010-03-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).
To be Published, 2008
3D6H
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BU of 3d6h by Molmil
Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:2008-05-19
Release date:2010-03-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).
To be Published, 2008
3DEJ
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BU of 3dej by Molmil
Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor: (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3
Authors:Wu, J, Du, J, Li, J, Ding, J.
Deposit date:2008-06-10
Release date:2008-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species
J.Biol.Chem., 283, 2008
1K88
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BU of 1k88 by Molmil
Crystal structure of procaspase-7
Descriptor: procaspase-7
Authors:Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y.
Deposit date:2001-10-23
Release date:2001-11-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001

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