PDB: 342 resultsInfo pagesStatus searchChemie searchBIRD

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1PAU	Crystal structure of the complex of apopain with the tetrapeptide aldehyde inhibitor AC-DEVD-CHO Descriptor: ACE-ASP-GLU-VAL-ASJ, APOPAIN Authors: Rotonda, J, Becker, J.W. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat.Struct.Biol., 3, 1996
1PYO	Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho Descriptor: ACETYL-LEU-ASP-GLU-SER-ASJ, Caspase-2 Authors: Schweizer, A, Briand, C, Grutter, M.G. Deposit date: 2003-07-09 Release date: 2003-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J.Biol.Chem., 278, 2003
1M72	Crystal Structure of Caspase-1 from Spodoptera frugiperda Descriptor: 1,2-ETHANEDIOL, Ace-Asp-Glu-Val-Asp-chloromethylketone, Caspase-1 Authors: Forsyth, C.M, Lemongello, D, Friesen, P.D, Fisher, A.J. Deposit date: 2002-07-18 Release date: 2004-01-20 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of an invertebrate caspase. J.Biol.Chem., 279, 2004
1QDU	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK Descriptor: CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR Authors: Blanchard, H, Grutter, M.G. Deposit date: 1999-07-10 Release date: 2000-07-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure Fold.Des., 7, 1999
7WR0	P32 of caspase-4 C258A mutant Descriptor: Caspase-4 Authors: Hou, Y.J, Zeng, H, Shao, F, Ding, J. Deposit date: 2022-01-26 Release date: 2023-01-25 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
6BFJ	Caspase-3 Mutant - T245D,S249D Descriptor: AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.543 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BG0	Caspase-3 Mutant - D9A,D28A,S150D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-27 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (2.125 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BFL	Caspase-3 Mutant- D9A,D28A,T245D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BFO	Caspase-3 Mutant- T245D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BG4	Caspase-3 Mutant- T152D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, CHLORIDE ION, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-27 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BDV	Crystal structure of Caspase 3 S150A Descriptor: AZIDE ION, Acetyl-Asp-Glu-Val-Asp-CMK, CHLORIDE ION, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-24 Release date: 2018-02-14 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.938 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BFK	Caspase-3 Mutant- T245A Descriptor: AC-ASP-GLU-VAL-ASP-CMK, Caspase-3, SODIUM ION Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.753 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BG1	Caspase-3 Mutant - D9A,D28A,S150E Descriptor: AC-ASP-GLU-VAL-ASP-CMK, Caspase-3, SODIUM ION Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-27 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BGR	Caspase-3 Mutant - S150E Descriptor: AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-29 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
1IBC	CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME Descriptor: INTERLEUKIN-1BETA CONVERTING ENZYME, PEPTIDE ACE-TRP-GLU-HIS-ASA Authors: Becker, J.W, Rotonda, J. Deposit date: 1997-02-12 Release date: 1998-02-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.73 Å) Cite: A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem.Biol., 4, 1997
1ICE	STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME Descriptor: INTERLEUKIN-1 BETA CONVERTING ENZYME, TETRAPEPTIDE ALDEHYDE Authors: Wilson, K.P, Griffith, J.P, Kim, E.E, Navia, M.A. Deposit date: 1994-09-29 Release date: 1995-07-28 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure and mechanism of interleukin-1 beta converting enzyme. Nature, 370, 1994
3DEH	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors Descriptor: Caspase-3, isoquinoline-1,3,4(2H)-trione Authors: Wu, J, Du, J, Li, J, Ding, J. Deposit date: 2008-06-10 Release date: 2008-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
3EDR	The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO Descriptor: Caspase-7, Inhibitor Ac-ldesd-cho peptide Authors: Agniswamy, J. Deposit date: 2008-09-03 Release date: 2008-10-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
3E4C	Procaspase-1 zymogen domain crystal structure Descriptor: Caspase-1, MAGNESIUM ION Authors: Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M. Deposit date: 2008-08-11 Release date: 2008-12-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284, 2009
3EDQ	Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO Descriptor: AC-LDESD-CHO peptide, Caspase-3 Authors: Fu, G. Deposit date: 2008-09-03 Release date: 2008-10-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
3D6F	Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published
3D6M	Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3D6H	Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3DEJ	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors Descriptor: (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 Authors: Wu, J, Du, J, Li, J, Ding, J. Deposit date: 2008-06-10 Release date: 2008-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
1K88	Crystal structure of procaspase-7 Descriptor: procaspase-7 Authors: Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. Deposit date: 2001-10-23 Release date: 2001-11-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001

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