6FVE
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7E45
| Crystal structure of compound 7 bound to MIF | Descriptor: | (2R)-7-[(2R,3R,4R,5S,6S)-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(4-methoxy-3-oxidanyl-phenyl)-5-oxidanyl-2,3-dihydrochromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Yang, L. | Deposit date: | 2021-02-10 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.433 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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2GDG
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4GRR
| characterization of N- and C- terminus mutants of human MIF | Descriptor: | (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor, ... | Authors: | Fan, C, Lolis, E. | Deposit date: | 2012-08-26 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Characterization of N- and C- terminus mutants of human MIF To be Published
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7E4A
| Crystal structure of MIF bound to compound 13 | Descriptor: | CHLORIDE ION, Flavoxate, Macrophage migration inhibitory factor, ... | Authors: | Fa, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.475 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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4Z1T
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8VG5
| Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC | Descriptor: | 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase | Authors: | Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. | Deposit date: | 2023-12-22 | Release date: | 2024-05-01 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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1GD0
| HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | Descriptor: | CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, SULFATE ION | Authors: | Kurihara, H, Katayama, N. | Deposit date: | 2000-08-24 | Release date: | 2001-02-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J.Med.Chem., 44, 2001
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6BG6
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4F2K
| Macrophage Migration Inhibitory Factor covalently complexed with phenethylisothiocyanate | Descriptor: | ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... | Authors: | Tyndall, J.D.A, Bernhagen, J, Hampton, M.B, Wilbanks, S.M, Rutledge, M.T. | Deposit date: | 2012-05-08 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate Acta Crystallogr.,Sect.F, 68, 2012
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6OYB
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6OYE
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6OY8
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9BNR
| 4-(2-isothiocyanatoethyl)benzenesulfonamide complexed with Macrophage Migration Inhibitory Factor | Descriptor: | Macrophage migration inhibitory factor, N-[2-(4-sulfamoylphenyl)ethyl]methanethioamide, SULFATE ION | Authors: | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | Deposit date: | 2024-05-02 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Chemmedchem, 2024
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1DPT
| D-DOPACHROME TAUTOMERASE | Descriptor: | D-DOPACHROME TAUTOMERASE | Authors: | Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I. | Deposit date: | 1998-05-11 | Release date: | 1999-03-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. Biochemistry, 38, 1999
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3CE4
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4K9G
| 1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound | Descriptor: | (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, CHLORIDE ION, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E.J. | Deposit date: | 2013-04-19 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45, 2014
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6OYG
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8DQ6
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7MRV
| F100A mutant structure of MIF2 (D-DT) | Descriptor: | D-dopachrome decarboxylase, SULFATE ION | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | Deposit date: | 2021-05-09 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. J.Biol.Chem., 297, 2021
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7E49
| Crystal structure of MIF bound to compound10 | Descriptor: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.574 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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3JSG
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8VFK
| Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT) | Descriptor: | CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION | Authors: | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | Deposit date: | 2023-12-21 | Release date: | 2024-05-01 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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4Z15
| MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one | Descriptor: | ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION | Authors: | Cho, T.Y. | Deposit date: | 2015-03-26 | Release date: | 2016-09-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
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7XVX
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