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3JSG

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution

Summary for 3JSG
Entry DOI10.2210/pdb3jsg/pdb
Related3JSF 3JTU
DescriptorMacrophage migration inhibitory factor, 7-(pyridin-3-ylmethyl)quinolin-8-ol, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, cytokine, cytoplasm, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted : P14174
Total number of polymer chains3
Total formula weight41275.62
Authors
Mclean, L.,Zhang, Y. (deposition date: 2009-09-10, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citationMcLean, L.R.,Zhang, Y.,Li, H.,Li, Z.,Lukasczyk, U.,Choi, Y.M.,Han, Z.,Prisco, J.,Fordham, J.,Tsay, J.T.,Reiling, S.,Vaz, R.J.,Li, Y.
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19:6717-6720, 2009
Cited by
PubMed: 19836948
DOI: 10.1016/j.bmcl.2009.09.106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.58 Å)
Structure validation

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