4K9G

1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound

Summary for 4K9G

• Entry DOI: 10.2210/pdb4k9g/pdb
• Related: 1LJT
• Descriptor: Macrophage migration inhibitory factor, (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, ... (6 entities in total)
• Functional Keywords: cytokine, secreted/endocytosed, isomerase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P14174
• Total number of polymer chains: 3
• Total formula weight: 38328.91

Authors

Crichlow, G.V.,Al-Abed, Y.,Lolis, E.J. (deposition date: 2013-04-19, release date: 2014-09-24, Last modification date: 2023-09-20)

• Primary citation: Ioannou, K.,Cheng, K.F.,Crichlow, G.V.,Birmpilis, A.I.,Lolis, E.J.,Tsitsilonis, O.E.,Al-Abed, Y.; ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.; INT J ONCOL., 45:1457-1468, 2014; PubMed: 25050663; DOI: 10.3892/ijo.2014.2551

Experimental method

X-RAY DIFFRACTION (1.55 Å)