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8R5W
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BU of 8r5w by Molmil
Crystal structure of the three anaphylatoxin-like modules in fibulin-2
Descriptor: Fibulin-2
Authors:Sohail, A.A, Koski, M.K, Ruddock, L.W.
Deposit date:2023-11-18
Release date:2024-07-10
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biophysical and structural studies of fibulin-2.
Sci Rep, 14, 2024
4UU9
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BU of 4uu9 by Molmil
Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
Descriptor: COMPLEMENT C5, MEDI7814, SULFATE ION
Authors:Colley, C, Sridharan, S, Dobson, C, Popovic, B, Debreczeni, J.E, Hargreaves, D, Edwards, B, Brennan, J, England, L, Fung, S, An Eghobamien, L, Sivars, U, Woods, R, Flavell, L, Renshaw, G.J, Wickson, K, Wilkinson, T, Davies, R, Bonnell, J, Warrener, P, Howes, R, Vaughan, T.
Deposit date:2014-07-25
Release date:2015-08-12
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
MAbs, 10, 2018
5B4P
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BU of 5b4p by Molmil
Complex structure of human C5a and its binding repebody
Descriptor: C5a anaphylatoxin, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Kim, H.-S, Choi, J.M, Hwang, D.E.
Deposit date:2016-04-12
Release date:2017-04-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complex structure of human C5a and its binding repebody
To Be Published
1KJS
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BU of 1kjs by Molmil
NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES
Descriptor: C5A
Authors:Zhang, X, Boyar, W, Toth, M, Wennogle, L, Gonnella, N.C.
Deposit date:1997-01-09
Release date:1997-05-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy.
Proteins, 28, 1997
1C5A
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BU of 1c5a by Molmil
THREE-DIMENSIONAL STRUCTURE OF PORCINE C5ADES*ARG FROM 1H NUCLEAR MAGNETIC RESONANCE DATA
Descriptor: COMPLEMENT C5A ANAPHYLATOXIN
Authors:Williamson, M.P, Madison, V.S.
Deposit date:1990-06-12
Release date:1991-10-15
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Three-dimensional structure of porcine C5adesArg from 1H nuclear magnetic resonance data.
Biochemistry, 29, 1990
1CFA
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BU of 1cfa by Molmil
SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES
Descriptor: COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST, SYNTHETIC N-TERMINAL TAIL
Authors:Zhang, X, Boyar, W, Galakatos, N, Gonnella, N.C.
Deposit date:1996-09-21
Release date:1997-09-17
Last modified:2024-06-05
Method:SOLUTION NMR
Cite:Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
Protein Sci., 6, 1997
4WB3
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BU of 4wb3 by Molmil
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin
Descriptor: ACETATE ION, CALCIUM ION, Complement C5, ...
Authors:Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
Deposit date:2014-09-02
Release date:2015-05-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
4WB2
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BU of 4wb2 by Molmil
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin
Descriptor: ACETATE ION, CALCIUM ION, Complement C5, ...
Authors:Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
Deposit date:2014-09-02
Release date:2015-05-06
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
6JV7
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BU of 6jv7 by Molmil
Chimeric Rat C5a
Descriptor: Chimeric-rC5a, D-anaphylatoxin C5a, SULFATE ION
Authors:Zuo, C.
Deposit date:2019-04-16
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.309 Å)
Cite:Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
3HQB
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BU of 3hqb by Molmil
Crystal structure of human desarg-C5A
Descriptor: Complement C5
Authors:Cook, W.J, Ealick, S.E.
Deposit date:2009-06-05
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66, 2010
3HQA
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BU of 3hqa by Molmil
Crystal structure of human desarg-C5A
Descriptor: Complement C5
Authors:Cook, W.J, Ealick, S.E.
Deposit date:2009-06-05
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.586 Å)
Cite:Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66, 2010
6JV8
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BU of 6jv8 by Molmil
Crystal structure of Rat C5a
Descriptor: Complement C5
Authors:Zuo, C.
Deposit date:2019-04-16
Release date:2020-04-22
Method:X-RAY DIFFRACTION (1.582 Å)
Cite:Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
4HW5
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BU of 4hw5 by Molmil
Crystal Structure of the Human C3a anaphylatoxin
Descriptor: Complement C3, SULFATE ION
Authors:Bajic, G, Yatime, L, Andersen, G.R.
Deposit date:2012-11-07
Release date:2012-12-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
4I6O
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BU of 4i6o by Molmil
Crystal structure of chemically synthesized human anaphylatoxin C3a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Complement C3
Authors:Wang, C.I.A, Ghassemian, A, Collins, B, Lewis, R.J, Alewood, P.F, Durek, T.
Deposit date:2012-11-29
Release date:2013-02-27
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Efficient chemical synthesis of human complement protein C3a.
Chem.Commun.(Camb.), 49, 2013
4HWJ
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BU of 4hwj by Molmil
Crystal Structure of the Human C3a desArg anaphylatoxin
Descriptor: Complement C3, SULFATE ION
Authors:Bajic, G, Yatime, L, Andersen, G.R.
Deposit date:2012-11-08
Release date:2012-12-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
4P3B
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BU of 4p3b by Molmil
Crystal structure of the mouse C5a-desArg anaphylatoxin
Descriptor: Complement C5, FORMIC ACID
Authors:Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
4P3A
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BU of 4p3a by Molmil
Crystal structure of the mouse C5a anaphylatoxin
Descriptor: Complement C5, FORMIC ACID
Authors:Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
4P39
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BU of 4p39 by Molmil
Crystal structure of the human C5aR antagonist C5a-A8
Descriptor: Complement C5
Authors:Yatime, L, Schatz-Jakobsen, J.A, Larsen, C, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
2A73
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BU of 2a73 by Molmil
Human Complement Component C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
8CEM
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BU of 8cem by Molmil
Structure of bovine native C3, re-refinement
Descriptor: Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Andersen, G.R, Fredslund, F.
Deposit date:2023-02-02
Release date:2023-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
4E0S
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BU of 4e0s by Molmil
Crystal Structure of C5b-6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ...
Authors:Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
3CU7
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BU of 3cu7 by Molmil
Human Complement Component 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Fredslund, F, Andersen, G.R.
Deposit date:2008-04-16
Release date:2008-06-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
7Y64
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BU of 7y64 by Molmil
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Descriptor: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
Deposit date:2022-06-18
Release date:2023-03-01
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
3KLS
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BU of 3kls by Molmil
Structure of complement C5 in complex with SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010

 

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數據於2024-09-18公開中

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