PDB: 67 件ウェブページステータス検索Chemie searchBIRD

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6YI9	Crystal structure of the rat cytosolic PCK1, acetylated on Lys244 分子名称: 1,2-ETHANEDIOL, Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 著者 Latorre-Muro, P, Baeza, J, Hurtado-Guerrero, R, Hicks, T, Delso, I, Hernandez-Ruiz, C, Velazquez-Campoy, A, Lawton, A.J, Angulo, J, Denu, J.M, Carrodeguas, J.A. 登録日 2020-04-01 公開日 2020-12-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. J.Biol.Chem., 296, 2021
6P5O	The structure of rat cytosolic PEPCK in complex with 3-(carboxymethylthiol)-picolinic acid 分子名称: 3-[(carboxymethyl)sulfanyl]pyridine-2-carboxylic acid, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Mcleod, M.J, Holyoak, T. 登録日 2019-05-30 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase. Biochemistry, 58, 2019
2ZCI	Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum 分子名称: Phosphoenolpyruvate carboxykinase [GTP] 著者 Aich, S, Prasad, L, Delbaere, L.T.J. 登録日 2007-11-09 公開日 2008-04-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum. Int.J.Biochem.Cell Biol., 40, 2008
4OX2	I45T cytosolic phosphoenolpyruvate carboxykinase in complex with beta-sulfopyruvate and GTP 分子名称: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Holyoak, T. 登録日 2014-02-04 公開日 2014-06-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Mol.Genet.Metab., 113, 2014
5I67	Crystal Structure Analysis of MTB PEPCK mutant C273S 分子名称: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Dostal, J, Pachl, P, Machova, I, Pichova, I, Snasel, J. 登録日 2016-02-16 公開日 2016-04-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Crystal Structure Analysis of MTB PEPCK mutant C273S To Be Published
2GMV	PEPCK complex with a GTP-competitive inhibitor 分子名称: MANGANESE (II) ION, N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE, PHOSPHOENOLPYRUVATE, ... 著者 Dunten, P. 登録日 2006-04-07 公開日 2007-05-29 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg.Med.Chem.Lett., 17, 2007
1NHX	PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR 分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ... 著者 Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J. 登録日 2002-12-19 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
4RCG	Crystal Structure Analysis of MTB PEPCK without Mn+2 分子名称: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Brynda, J, Dostal, J, Snasel, J, Fanfrlik, J, Pichova, I, Machova, I. 登録日 2014-09-16 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
4R43	Crystal Structure Analysis of MTB PEPCK 分子名称: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Brynda, J, Dostal, J, Pichova, I, Snasel, J, Fanfrlik, J, Machova, I. 登録日 2014-08-19 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
1M51	PEPCK complex with a GTP-competitive inhibitor 分子名称: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... 著者 Foley, L.H, Wang, P, Dunten, P, Wertheimer, S.J. 登録日 2002-07-06 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
2FAF	The structure of chicken mitochondrial PEPCK. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... 著者 Holyoak, T, Sullivan, S.M, Nowak, T. 登録日 2005-12-07 公開日 2006-06-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insights into the Mechanism of PEPCK Catalysis Biochemistry, 45, 2006
2FAH	The structure of mitochondrial PEPCK, Complex with Mn and GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MALONIC ACID, MANGANESE (II) ION, ... 著者 Holyoak, T, Sullivan, S.M, Nowak, T. 登録日 2005-12-07 公開日 2006-06-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural Insights into the Mechanism of PEPCK Catalysis Biochemistry, 45, 2006
5FH1	The structure of rat cytosolic PEPCK variant E89D in complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-12-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH0	The structure of rat cytosolic PEPCK variant E89A complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH4	The structure of rat cytosolic PEPCK variant E89D in complex with beta-sulfopyruvate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
7L3V	PEPCK MMQX structure 120ms post-mixing with oxaloacetic acid 分子名称: CARBON DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E. 登録日 2020-12-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection. Iucrj, 8, 2021
7L36	PEPCK steady-state structure with Mn and GTP 分子名称: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E. 登録日 2020-12-17 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection. Iucrj, 8, 2021
7L3M	PEPCK MMQX structure 40ms post-mixing with oxaloacetic acid 分子名称: CARBON DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E. 登録日 2020-12-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection. Iucrj, 8, 2021
3MOE	The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2010-04-22 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
3MOF	The structure of rat cytosolic PEPCK mutant A467G in complex with oxalate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2010-04-22 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
3MOH	The structure of rat cytosolic PEPCK mutant A467G in complex with phosphoglycolate and GDP 分子名称: 1,2-ETHANEDIOL, 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2010-04-22 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
5FH2	The structure of rat cytosolic PEPCK variant E89Q in complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH3	The structure of rat cytosolic PEPCK variant E89A in complex with oxalic acid and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH5	The structure of rat cytosolic PEPCK variant E89Q in complex with phosphoglycolate and GDP 分子名称: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
4YW9	Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and GTP 分子名称: 3-sulfanylpyridine-2-carboxylic acid, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T. 登録日 2015-03-20 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015

 

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