8C8T
 
 | | cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Baquero, E, Molinos-Albert, L, Mouquet, H. | | 登録日 | 2023-01-21 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.
Cell Host Microbe, 31, 2023
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1B03
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3NGB
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4LSU
 | | Crystal structure of broadly and potently neutralizing antibody VRC-PG20 in complex with HIV-1 clade A/E 93TH057 gp120 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Zhou, T, Moquin, S, Kwong, P.D. | | 登録日 | 2013-07-23 | | 公開日 | 2013-08-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
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2BF1
 | | Structure of an unliganded and fully-glycosylated SIV gp120 envelope glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, B, Vogan, E.M, Gong, H, Skehel, J.J, Wiley, D.C, Harrison, S.C. | | 登録日 | 2004-12-02 | | 公開日 | 2005-02-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structure of an Unliganded Simian Immunodeficiency Virus Gp120 Core
Nature, 433, 2005
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2I60
 | | Crystal structure of [Phe23]M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B HEAVY CHAIN, ANTIBODY 17B LIGHT CHAIN, ... | | 著者 | Huang, C.-C, Kwong, P.D. | | 登録日 | 2006-08-26 | | 公開日 | 2006-10-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.
J.Mol.Biol., 382, 2008
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1YYL
 | | crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD4M33, scorpion-toxin mimic of CD4, ... | | 著者 | Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D. | | 登録日 | 2005-02-25 | | 公開日 | 2005-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
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1YYM
 | | crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120), ... | | 著者 | Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D. | | 登録日 | 2005-02-25 | | 公開日 | 2005-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
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5KJR
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5IGX
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5I9Q
 | | Crystal structure of 3BNC55 Fab in complex with 426c.TM4deltaV1-3 gp120 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC55 Fab heavy chain, ... | | 著者 | Scharf, L, Chen, C, Bjorkman, P.J. | | 登録日 | 2016-02-20 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for germline antibody recognition of HIV-1 immunogens.
Elife, 5, 2016
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7JKS
 | | Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2411a in complex with HIV-1 gp120 core | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 gp120 core, The heavy chain of antibody 2411a, ... | | 著者 | Zhou, T, Chen, X, Kwong, P.D, Mascola, J.R. | | 登録日 | 2020-07-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
Immunity, 54, 2021
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7JKT
 | | Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2413a in complex with HIV-1 gp120 core | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 gp120 core from strain d45-01dG5, ... | | 著者 | Zhou, T, Chen, X, Kwong, P.D, Mascola, J.R. | | 登録日 | 2020-07-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
Immunity, 54, 2021
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5TE4
 | | Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhou, T, Kwong, P.D. | | 登録日 | 2016-09-20 | | 公開日 | 2016-11-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
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6BF4
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6BCK
 | | Crystal Structure of Broadly Neutralizing Antibody N49P7 in Complex with HIV-1 Clade AE strain 93TH057 gp120 core. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N49P7 Fab heavy chain of N29P7 IgG, ... | | 著者 | Tolbert, W.D, Gohain, N, Pazgier, M. | | 登録日 | 2017-10-20 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.
Cell, 173, 2018
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6P8M
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6P9N
 | | CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH (S)-MCG-IV-210. | | 分子名称: | (3S)-N~1~-(2-aminoethyl)-N~3~-(4-chloro-3-fluorophenyl)piperidine-1,3-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Tolbert, W.D, Sherburn, R, Pazgier, M. | | 登録日 | 2019-06-10 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
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3DNO
 | | Molecular structure for the HIV-1 gp120 trimer in the CD4-bound state | | 分子名称: | HIV-1 envelope glycoprotein gp120 | | 著者 | Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S. | | 登録日 | 2008-07-02 | | 公開日 | 2008-08-19 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | Molecular architecture of native HIV-1 gp120 trimers.
Nature, 455, 2008
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3DNN
 | | Molecular structure for the HIV-1 gp120 trimer in the unliganded state | | 分子名称: | HIV-1 envelope glycoprotein gp120 | | 著者 | Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S. | | 登録日 | 2008-07-02 | | 公開日 | 2008-08-19 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | Molecular architecture of native HIV-1 gp120 trimers.
Nature, 455, 2008
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3DNL
 | | Molecular structure for the HIV-1 gp120 trimer in the b12-bound state | | 分子名称: | HIV-1 envelope glycoprotein gp120 | | 著者 | Borgnia, M.J, Liu, J, Bartesaghi, A, Sapiro, G, Subramaniam, S. | | 登録日 | 2008-07-02 | | 公開日 | 2008-08-19 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | Molecular architecture of native HIV-1 gp120 trimers.
Nature, 455, 2008
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3FUS
 | | Improved Structure of the Unliganded Simian Immunodeficiency Virus gp120 Core | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, X, Poon, B, Wang, Q, Ma, J. | | 登録日 | 2009-01-14 | | 公開日 | 2009-06-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement.
Acta Crystallogr.,Sect.D, 65, 2009
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4XVS
 | | Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Light chain, Donor 45 01dG5 coreE gp120, ... | | 著者 | Joyce, M.G, Mascola, J.R, Kwong, P.D. | | 登録日 | 2015-01-27 | | 公開日 | 2015-05-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell, 161, 2015
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4XVT
 | | Crystal structure of HIV-1 93TH057 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) Light chain, ENVELOPE GLYCOPROTEIN GP120 OF HIV-1 CLADE A/E, ... | | 著者 | Joyce, M.G, Mascola, J.R, Kwong, P.D. | | 登録日 | 2015-01-28 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell, 161, 2015
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4YDI
 | | Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Zhou, T, Srivatsan, S, Kwong, P.D. | | 登録日 | 2015-02-22 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.452 Å) | | 主引用文献 | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
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