7JKS

Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2411a in complex with HIV-1 gp120 core

Summary for 7JKS

Entry DOI	10.2210/pdb7jks/pdb
Descriptor	HIV-1 gp120 core, The heavy chain of antibody 2411a, The light chain of antibody 2411a, ... (6 entities in total)
Functional Keywords	broadly neutralizing antibody, vrc01-class, vaccine-elicited, hiv-1, immune system
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	3
Total formula weight	93002.73
Authors	Zhou, T.,Chen, X.,Kwong, P.D.,Mascola, J.R. (deposition date: 2020-07-28, release date: 2021-06-09, Last modification date: 2023-10-18)
Primary citation	Chen, X.,Zhou, T.,Schmidt, S.D.,Duan, H.,Cheng, C.,Chuang, G.Y.,Gu, Y.,Louder, M.K.,Lin, B.C.,Shen, C.H.,Sheng, Z.,Zheng, M.X.,Doria-Rose, N.A.,Joyce, M.G.,Shapiro, L.,Tian, M.,Alt, F.W.,Kwong, P.D.,Mascola, J.R. Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity, 54:324-339.e8, 2021 Cited by PubMed: 33453152 DOI: 10.1016/j.immuni.2020.12.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation