3NGB

Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120

Summary for 3NGB

• Entry DOI: 10.2210/pdb3ngb/pdb
• Descriptor: Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ... (9 entities in total)
• Functional Keywords: hiv, gp120, antibody, vrc01, neutralization, vaccine, envelope glycoprotein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 363536.47

Authors

Zhou, T.,Kwong, P.D. (deposition date: 2010-06-11, release date: 2010-07-07, Last modification date: 2023-09-06)

• Primary citation: Zhou, T.,Georgiev, I.,Wu, X.,Yang, Z.Y.,Dai, K.,Finzi, A.,Do Kwon, Y.,Scheid, J.F.,Shi, W.,Xu, L.,Yang, Y.,Zhu, J.,Nussenzweig, M.C.,Sodroski, J.,Shapiro, L.,Nabel, G.J.,Mascola, J.R.,Kwong, P.D.; Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.; Science, 329:811-817, 2010; PubMed: 20616231; DOI: 10.1126/science.1192819

Experimental method

X-RAY DIFFRACTION (2.68 Å)