8CEF
 
 | | Asymmetric Dimerization in a Transcription Factor Superfamily is Promoted by Allosteric Interactions with DNA | | 分子名称: | DNA (26-MER), Nuclear receptor DNA binding domain, ZINC ION | | 著者 | Patel, A.K.M, Shaik, T.B, McEwen, A.G, Moras, D, Klaholz, B.P, Billas, I.M.L. | | 登録日 | 2023-02-01 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.486 Å) | | 主引用文献 | Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.
Nucleic Acids Res., 51, 2023
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2A66
 | | Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter | | 分子名称: | 5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3', 5'-D(*GP*TP*TP*CP*AP*AP*GP*GP*CP*CP*AP*G)-3', ACETATE ION, ... | | 著者 | Solomon, I.H, Hager, J.M, Safi, R, McDonnell, D.P, Redinbo, M.R, Ortlund, E.A. | | 登録日 | 2005-07-01 | | 公開日 | 2005-12-06 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of the Human LRH-1 DBD-DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity.
J.Mol.Biol., 354, 2005
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4AA6
 | | The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation | | 分子名称: | 5'-D(*CP*TP*AP*AP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP *CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP *CP*TP*TP*A)-3', ESTROGEN RECEPTOR, ... | | 著者 | Schwabe, J.W, Chapman, L, Rhodes, D. | | 登録日 | 2011-11-30 | | 公開日 | 2011-12-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation.
Structure, 3, 1995
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3M9E
 | | Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE | | 分子名称: | DNA (5'-D(*AP*TP*TP*GP*AP*CP*CP*TP*CP*AP*GP*CP*TP*GP*AP*GP*GP*TP*CP*AP*AP*T)-3'), Thyroid hormone receptor beta, ZINC ION | | 著者 | Chen, Y. | | 登録日 | 2010-03-22 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | | 主引用文献 | Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.
Mol.Endocrinol., 24, 2010
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1YNW
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2NLL
 | | RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA | | 分子名称: | DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ... | | 著者 | Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B. | | 登録日 | 1996-11-20 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural determinants of nuclear receptor assembly on DNA direct repeats.
Nature, 375, 1995
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1R0O
 | | Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex | | 分子名称: | Ecdysone Response Element, Ecdysone receptor, Ultraspiracle protein, ... | | 著者 | Devarakonda, S, Harp, J.M, Kim, Y, Ozyhar, A, Rastinejad, F. | | 登録日 | 2003-09-22 | | 公開日 | 2003-10-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex
Embo J., 22, 2003
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1A6Y
 | | REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX | | 分子名称: | DNA (5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*(5IT)P*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3'), ORPHAN NUCLEAR RECEPTOR NR1D1, ... | | 著者 | Zhao, Q, Khorasanizadeh, S, Rastinejad, F. | | 登録日 | 1998-03-04 | | 公開日 | 1998-10-21 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural elements of an orphan nuclear receptor-DNA complex.
Mol.Cell, 1, 1998
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1HCP
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8RM6
 | | Crystal Structure of Human Androgen Receptor DNA Binding Domain Bound to its Response Element: C3(1)ARE | | 分子名称: | C3(1)ARE_Chain C, C3(1)ARE_Chain D, Isoform 2 of Androgen receptor, ... | | 著者 | Lee, X.Y, Helsen, C, Van Eynde, W, Voet, A, Claessens, F. | | 登録日 | 2024-01-05 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural mechanism underlying variations in DNA binding by the androgen receptor.
J.Steroid Biochem.Mol.Biol., 241, 2024
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8RM7
 | | Crystal Structure of Human Androgen Receptor DNA Binding Domain Bound to its Response Element: MMTV-177 GRE/ARE | | 分子名称: | Isoform 2 of Androgen receptor, MMTV-177 GRE/ARE Chain C, MMTV-177 GRE/ARE, ... | | 著者 | Lee, X.Y, Helsen, C, Van Eynde, W, Voet, A, Claessens, F. | | 登録日 | 2024-01-05 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural mechanism underlying variations in DNA binding by the androgen receptor.
J.Steroid Biochem.Mol.Biol., 241, 2024
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1HLZ
 | | CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT | | 分子名称: | 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ... | | 著者 | Sierk, M.L, Zhao, Q, Rastinejad, F. | | 登録日 | 2000-12-04 | | 公開日 | 2001-11-16 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | DNA Deformability as a Recognition Feature in the RevErb Response Element
Biochemistry, 40, 2001
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1R0N
 | | Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex | | 分子名称: | Ecdsyone Response Element, Ecdysone Response Element, Ecdysone receptor, ... | | 著者 | Devarakonda, S, Harp, J.M, Kim, Y, Ozyhar, A, Rastinejad, F. | | 登録日 | 2003-09-22 | | 公開日 | 2003-10-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the heterodimeric Ecdysone Receptor DNA-binding complex
Embo J., 22, 2003
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5L0M
 | | hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex | | 分子名称: | DNA (5'-D(*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*G)-3'), GLYCEROL, ... | | 著者 | Tuntland, M.L, Ortlund, E.A. | | 登録日 | 2016-07-27 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | | 主引用文献 | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
J. Mol. Biol., 428, 2016
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5KRB
 | | GCNF DNA Binding Domain - Oct4 DR0 Complex | | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*CP*TP*CP*T)-3'), Nuclear receptor subfamily 6 group A member 1, ... | | 著者 | Weikum, E.R, Ortlund, E.A. | | 登録日 | 2016-07-07 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
J. Mol. Biol., 428, 2016
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1BY4
 | | STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA | | 分子名称: | DNA (5'-D(*C*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*A)-3'), PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA), ... | | 著者 | Zhao, Q, Chasse, S.A, Devarakonda, S, Sierk, M.L, Ahvazi, B, Sigler, P.B, Rastinejad, F. | | 登録日 | 1998-10-22 | | 公開日 | 2000-01-12 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of RXR-DNA interactions.
J.Mol.Biol., 296, 2000
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4TNT
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2HAN
 | | Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter | | 分子名称: | 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP*AP*CP*TP*TP*GP*T)-3', 5'-D(*GP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*AP*AP*CP*CP*CP*TP*T)-3', Ecdysone receptor, ... | | 著者 | Jakob, M, Kolodziejczyk, R, Orlowski, M, Krzywda, S, Kowalska, A, Dutko-Gwozdz, J, Gwozdz, T, Kochman, M, Jaskolski, M, Ozyhar, A. | | 登録日 | 2006-06-13 | | 公開日 | 2007-05-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain.
Nucleic Acids Res., 35, 2007
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2GDA
 | | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | | 分子名称: | GLUCOCORTICOID RECEPTOR, ZINC ION | | 著者 | Baumann, H, Paulsen, K, Kovacs, H, Berglund, H, Wright, A.P.H, Gustafsson, J.-A, Hard, T. | | 登録日 | 1994-03-15 | | 公開日 | 1994-06-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined solution structure of the glucocorticoid receptor DNA-binding domain.
Biochemistry, 32, 1993
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6FBQ
 | | Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 7.0 | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... | | 著者 | McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. | | 登録日 | 2017-12-19 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Modulation of RXR-DNA complex assembly by DNA context.
Mol. Cell. Endocrinol., 481, 2019
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6FBR
 | | Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 4.2 | | 分子名称: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... | | 著者 | McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. | | 登録日 | 2017-12-19 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Modulation of RXR-DNA complex assembly by DNA context.
Mol. Cell. Endocrinol., 481, 2019
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4HN5
 | | GR DNA Binding Domain - TSLP nGRE Complex | | 分子名称: | DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... | | 著者 | Hudson, W.H, Youn, C.E, Ortlund, E.A. | | 登録日 | 2012-10-18 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
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8HBM
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5VA0
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8IFO
 | | Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter | | 分子名称: | DNA (5'-D(*GP*AP*GP*GP*AP*CP*AP*AP*AP*GP*GP*TP*GP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*CP*AP*CP*CP*TP*TP*TP*GP*TP*CP*CP*TP*C)-3'), Estrogen-related receptor gamma, ... | | 著者 | Xu, T, Zhen, X, Liu, J. | | 登録日 | 2023-02-19 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element.
Biochem.Biophys.Res.Commun., 656, 2023
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