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2FTK
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BU of 2ftk by Molmil
berylloflouride Spo0F complex with Spo0B
Descriptor: MAGNESIUM ION, Sporulation initiation phosphotransferase B, Sporulation initiation phosphotransferase F
Authors:Varughese, K.I.
Deposit date:2006-01-24
Release date:2006-07-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The Crystal Structure of Beryllofluoride Spo0F in Complex with the Phosphotransferase Spo0B Represents a Phosphotransfer Pretransition State.
J.Bacteriol., 188, 2006
1AEC
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BU of 1aec by Molmil
CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+
Descriptor: ACTINIDIN, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE
Authors:Varughese, K.I.
Deposit date:1992-02-05
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of an actinidin-E-64 complex.
Biochemistry, 31, 1992
1DHR
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BU of 1dhr by Molmil
CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Skinner, M.M, Whiteley, J.M, Matthews, D.A, Xuong, N.H.
Deposit date:1992-03-30
Release date:1993-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat liver dihydropteridine reductase.
Proc.Natl.Acad.Sci.USA, 89, 1992
1QYY
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BU of 1qyy by Molmil
Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PLATINUM (II) ION, Platelet glycoprotein Ib alpha chain, ...
Authors:Varughese, K.I, Ruggeri, Z.M, Celikel, R.
Deposit date:2003-09-12
Release date:2004-03-02
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain.
Acta Crystallogr.,Sect.D, 60, 2004
1IXM
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BU of 1ixm by Molmil
CRYSTAL STRUCTURE OF SPOOB FROM BACILLUS SUBTILIS
Descriptor: PROTEIN (SPORULATION RESPONSE REGULATORY PROTEIN)
Authors:Varughese, K.I.
Deposit date:1998-11-06
Release date:1998-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase.
Mol.Cell, 2, 1998
3PMH
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BU of 3pmh by Molmil
Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, Platelet glycoprotein Ib alpha chain, ...
Authors:Varughese, K.I, Celikel, R.
Deposit date:2010-11-16
Release date:2011-06-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
Proc.Natl.Acad.Sci.USA, 108, 2011
1FNS
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BU of 1fns by Molmil
CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4
Descriptor: IMMUNOGLOBULIN NMC-4 IGG1, VON WILLEBRAND FACTOR
Authors:Varughese, K.I.
Deposit date:2000-08-23
Release date:2000-10-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule.
Nat.Struct.Biol., 7, 2000
1DIR
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BU of 1dir by Molmil
CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Su, Y, Skinner, M.M, Matthews, D.A, Whitely, J.M, Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1P9A
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BU of 1p9a by Molmil
Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 1.7 Angstrom Resolution
Descriptor: Platelet glycoprotein Ib alpha chain precursor, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Varughese, K.I, Celikel, R, Ruggeri, Z.M.
Deposit date:2003-05-09
Release date:2003-07-22
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
Science, 301, 2003
1OOK
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BU of 1ook by Molmil
Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Human Alpha Thrombin, ...
Authors:Varughese, K.I, Celikel, R, Ruggeri, Z.M.
Deposit date:2003-03-03
Release date:2003-07-22
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
Science, 301, 2003
1HDR
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BU of 1hdr by Molmil
THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Su, Y, Xuong, N.H, Whiteley, J.M.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
J.Biol.Chem., 268, 1993
2ZKZ
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BU of 2zkz by Molmil
Crystal structure of the transcriptional repressor PagR of Bacillus anthracis
Descriptor: Transcriptional repressor pagR
Authors:Zhao, H, Volkov, A, Veldore, V.H, Varughese, K.I.
Deposit date:2008-04-01
Release date:2009-04-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the transcriptional repressor PagR of Bacillus anthracis
Microbiology, 156, 2010
3SL2
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BU of 3sl2 by Molmil
ATP Forms a Stable Complex with the Essential Histidine Kinase WalK (YycG) Domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Sensor histidine kinase yycG
Authors:Celikel, R, Veldore, V.H, Mathews, I, Devine, K, Varughese, K.I.
Deposit date:2011-06-23
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.
Acta Crystallogr.,Sect.D, 68, 2012
7XMP
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BU of 7xmp by Molmil
High resolution structure of lectin-like Ox-LDL receptor 1 in space group P 32 2 1
Descriptor: Oxidized low-density lipoprotein receptor 1
Authors:Tomar, A, Varughese, K.I, Arockiasamy, A.
Deposit date:2022-04-26
Release date:2023-05-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:High resolution structure of lectin like Ox-LDL receptor 1 in space group P 32 2 1
To Be Published
3GM0
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BU of 3gm0 by Molmil
Anti-methamphetamine single chain Fv in complex with MDMA
Descriptor: (2S)-1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine, anti-methamphetamine single chain Fv
Authors:Celikel, R, Peterson, E.C, Owens, M, Varughese, K.I.
Deposit date:2009-03-12
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Protein Sci., 18, 2009
3GKZ
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BU of 3gkz by Molmil
Crystal structures of a therapeutic single chain antibody in complex methamphetamine
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, anti-methamphetamine single chain Fv
Authors:Celikel, R, Peterson, E.C, Owens, M, Varughese, K.I.
Deposit date:2009-03-11
Release date:2009-10-06
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Protein Sci., 18, 2009
2FGT
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BU of 2fgt by Molmil
Crystal Structure of YycH from Bacillus subtilis
Descriptor: Two-component system yycF/yycG regulatory protein yycH
Authors:Szurmant, H, Zhao, H, Mohan, M.A, James, H.A, Varughese, K.I.
Deposit date:2005-12-22
Release date:2006-04-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
Protein Sci., 15, 2006
1OAK
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BU of 1oak by Molmil
CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC-4 FAB
Descriptor: NMC-4 IGG1, VON WILLEBRAND FACTOR
Authors:Celikel, R, Varughese, K.I.
Deposit date:1997-12-18
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab.
Nat.Struct.Biol., 5, 1998
4QRA
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BU of 4qra by Molmil
Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
Descriptor: CALCIUM ION, L,d-transpeptidase LdtB
Authors:Gokulan, K, Varughese, K.I.
Deposit date:2014-06-30
Release date:2015-12-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
To be Published
4QRB
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BU of 4qrb by Molmil
Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
Descriptor: GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA, L,d-transpeptidase LdtB
Authors:Gokulan, K, Varughese, K.I.
Deposit date:2014-06-30
Release date:2015-12-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
To be Published
4QTF
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Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
Descriptor: (3S,5S)-3-({[(aminomethyl)amino]methyl}sulfanyl)-5-[(2S)-1,3-dioxobutan-2-yl]-L-proline, GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA, L,d-transpeptidase LdtB
Authors:Gokulan, K, Varughese, K.I.
Deposit date:2014-07-07
Release date:2015-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
To be Published
4QR7
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BU of 4qr7 by Molmil
Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
Descriptor: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA, L,d-transpeptidase LdtB
Authors:Gokulan, K, Varughese, K.I.
Deposit date:2014-06-30
Release date:2015-07-29
Last modified:2022-02-02
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
To be Published
4GQP
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BU of 4gqp by Molmil
Structure based design of sub-nanomolar affinity anti-methamphetamine single chain antibodies.
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, Anti-METH scFv
Authors:Thakkar, S, Varughese, K.I.
Deposit date:2012-08-23
Release date:2013-10-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.
Sci Rep, 4, 2014
4LAR
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BU of 4lar by Molmil
Crystal structure of a therapeutic single chain antibody in complex with amphetamine
Descriptor: (2S)-1-phenylpropan-2-amine, Single chain antibody fragment scFv6H4
Authors:Celical, R, Gokulan, K, Peterson, E.C, Varughese, K.I.
Deposit date:2013-06-20
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.
Plos One, 8, 2013
4LAQ
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BU of 4laq by Molmil
Crystal structure of a therapeutic single chain antibody in the free form
Descriptor: D-MALATE, NICKEL (II) ION, SULFATE ION, ...
Authors:Celikel, R, Gokulan, K, Peterson, E.C, Varughese, K.I.
Deposit date:2013-06-20
Release date:2014-01-08
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.
Plos One, 8, 2013

 

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