3PMH

Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites

Summary for 3PMH

• Entry DOI: 10.2210/pdb3pmh/pdb
• Related: 1OOK
• Related PRD ID: PRD_000021
• Descriptor: THROMBIN ALPHA-CHAIN, THROMBIN BETA-CHAIN, Platelet glycoprotein Ib alpha chain, ... (6 entities in total)
• Functional Keywords: sulfated tyrosine residues, leucine rich repeats, protease platelet receptor of thrombin, thrombin binding, platelet surface, blood cloting, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 68006.73

Authors

Varughese, K.I.,Celikel, R. (deposition date: 2010-11-16, release date: 2011-06-01, Last modification date: 2023-12-06)

• Primary citation: Zarpellon, A.,Celikel, R.,Roberts, J.R.,McClintock, R.A.,Mendolicchio, G.L.,Moore, K.L.,Jing, H.,Varughese, K.I.,Ruggeri, Z.M.; Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.; Proc.Natl.Acad.Sci.USA, 108:8628-8633, 2011; PubMed: 21555542; DOI: 10.1073/pnas.1017042108

Experimental method

X-RAY DIFFRACTION (3.2 Å)