4GQP
Structure based design of sub-nanomolar affinity anti-methamphetamine single chain antibodies.
Summary for 4GQP
| Entry DOI | 10.2210/pdb4gqp/pdb |
| Related | 3GKZ |
| Descriptor | Anti-METH scFv, (2S)-N-methyl-1-phenylpropan-2-amine (3 entities in total) |
| Functional Keywords | antibody meth complex, immunoglobulin fold, anti-meth single chain antibody, free meth concentration, methamphetamine, vasculature, immune system |
| Biological source | Mus musculus |
| Total number of polymer chains | 1 |
| Total formula weight | 26955.60 |
| Authors | Thakkar, S.,Varughese, K.I. (deposition date: 2012-08-23, release date: 2013-10-02, Last modification date: 2023-09-13) |
| Primary citation | Thakkar, S.,Nanaware-Kharade, N.,Celikel, R.,Peterson, E.C.,Varughese, K.I. Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering. Sci Rep, 4:3673-3673, 2014 Cited by PubMed: 24419156DOI: 10.1038/srep03673 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
