1FNS
CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4
Summary for 1FNS
Entry DOI | 10.2210/pdb1fns/pdb |
Descriptor | IMMUNOGLOBULIN NMC-4 IGG1, VON WILLEBRAND FACTOR, ... (4 entities in total) |
Functional Keywords | von willebrand factor, glycoprotein iba (a:alpha) binding, complex (willebrand-immunoglobulin), blood coagulation type 2b von willebrand disease, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P04275 |
Total number of polymer chains | 3 |
Total formula weight | 70230.02 |
Authors | Varughese, K.I. (deposition date: 2000-08-23, release date: 2000-10-18, Last modification date: 2011-11-16) |
Primary citation | Celikel, R.,Ruggeri, Z.M.,Varughese, K.I. von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule. Nat.Struct.Biol., 7:881-884, 2000 Cited by PubMed: 11017197DOI: 10.1038/79639 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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