PDB: 5174 resultsInfo pagesStatus searchChemie searchBIRD

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8EK4	De novo designed ice-binding proteins from twist-constrained helices Descriptor: Ice-binding protein TIP-99a Authors: Bera, A.K, De Haas, R.J. Deposit date: 2022-09-19 Release date: 2023-07-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: De novo designed ice-binding proteins from twist-constrained helices. Proc.Natl.Acad.Sci.USA, 120, 2023
5WLJ	De Novo Design of Polynuclear Transition Metal Clusters in Helix Bundles-4EH1 Descriptor: De Novo Metal Binding Helical Bundle, ZINC ION Authors: Zhang, S.-Q, Liu, L, DeGrado, W.F. Deposit date: 2017-07-27 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J. Am. Chem. Soc., 140, 2018
8TN1	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - apo Descriptor: De novo designed 4 helix bundles, SULFATE ION Authors: Lu, L, DeGrado, W.F. Deposit date: 2023-08-01 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (1.61 Å) Cite: De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8TN6	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo rucaparib Descriptor: De novo designed protein, Rucaparib Authors: Lu, L, DeGrado, W.F. Deposit date: 2023-08-01 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8HDU	De novo design cavitated protein without predefined topology Descriptor: De novo design cavitated protein Authors: Hu, X, Xu, Y. Deposit date: 2022-11-06 Release date: 2023-01-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (2.71 Å) Cite: De novo design of cavity-containing proteins with a backbone-centered neural network energy function. Structure, 32, 2024
8HDV	De novo design cavitated protein without predefined topology Descriptor: De novo design cavitated protein Authors: Hu, X, Xu, Y. Deposit date: 2022-11-06 Release date: 2023-01-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (2.65 Å) Cite: De novo design of cavity-containing proteins with a backbone-centered neural network energy function. Structure, 32, 2024
7SKN	De novo synthetic protein DIG8-CC (tetragonal space group) Descriptor: De novo synthetic protein DIG8-CC Authors: Mendes, S.R, Eckhard, U, Marcos, E, Gomis-Ruth, F.X. Deposit date: 2021-10-21 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: De novo design of immunoglobulin-like domains Nat Commun, 13, 2022
7SKO	De novo synthetic protein DIG8-CC (orthogonal space group) Descriptor: De novo synthetic protein DIG8-CC, MAGNESIUM ION Authors: Mendes, S.R, Eckhard, U, Marcos, E, Gomis-Ruth, F.X. Deposit date: 2021-10-21 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.05 Å) Cite: De novo design of immunoglobulin-like domains Nat Commun, 13, 2022
7SKP	De novo synthetic protein DIG14 (tetragonal space group) Descriptor: De novo synthetic protein DIG14 Authors: Mendes, S.R, Eckhard, U, Marcos, E, Gomis-Ruth, F.X. Deposit date: 2021-10-21 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: De novo design of immunoglobulin-like domains Nat Commun, 13, 2022
6WI5	De novo designed protein Foldit4 Descriptor: De novo designed protein Foldit4 Authors: Bera, A.K, Koepnick, B, Boykov, A, Baker, D. Deposit date: 2020-04-08 Release date: 2020-04-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.83 Å) Cite: De novo design of protein logic gates. Science, 368, 2020
6MSP	De novo Designed Protein Foldit3 Descriptor: De novo Designed Protein Foldit3 Authors: Liu, G, Ishida, Y, Swapna, G.V.T, Kleinfelter, S, Koepnick, B, Baker, D, Montelione, G.T. Deposit date: 2018-10-17 Release date: 2019-06-12 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: De novo protein design by citizen scientists. Nature, 570, 2019
8TNB	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo mefuparib Descriptor: 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide, De novo designed protein Authors: Lu, L, DeGrado, W.F. Deposit date: 2023-08-01 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8TNC	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo niraparib Descriptor: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, De novo designed protein Authors: Lu, L, DeGrado, W.F. Deposit date: 2023-08-01 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8TND	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo veliparib Descriptor: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, De novo designed protein, SULFATE ION Authors: Lu, L, DeGrado, W.F. Deposit date: 2023-08-01 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (1.29 Å) Cite: De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8T5E	De novo design of high-affinity protein binders to bioactive helical peptides Descriptor: Bcl-2-like protein 11, Bim_fulldiff Authors: Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. Deposit date: 2023-06-13 Release date: 2024-01-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
8T5F	De novo design of high-affinity protein binders to bioactive helical peptides Descriptor: Parathyroid hormone Authors: Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. Deposit date: 2023-06-13 Release date: 2024-01-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.99 Å) Cite: De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
7CBC	Crystal structure of a de novo designed switch protein caging a hemagglutinin binder Descriptor: De novo designed switch protein caging a hemagglutinin binder (sCageHA267_1S), ETHANOL Authors: Lee, H, Oh, B.-H, Baker, D. Deposit date: 2020-06-11 Release date: 2020-12-23 Last modified: 2021-03-31 Method: X-RAY DIFFRACTION (1.99 Å) Cite: De novo design of modular and tunable protein biosensors. Nature, 591, 2021
8GJG	De novo design of high-affinity protein binders to bioactive helical peptides Descriptor: gluc_A04_0005, gluc_A04_0005 Binder Authors: Leung, P.J.Y, Bera, A.K, Torres, S.V, Baker, D, Kang, A. Deposit date: 2023-03-15 Release date: 2024-01-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
8GJI	De novo design of high-affinity protein binders to bioactive helical peptides Descriptor: GCG binder, Glucagon Authors: Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. Deposit date: 2023-03-15 Release date: 2024-01-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.81 Å) Cite: De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
1PBZ	DE NOVO DESIGNED PEPTIDE-METALLOPORPHYRIN COMPLEX, SOLUTION STRUCTURE Descriptor: COPROPORPHYRIN I CONTAINING CO(III), De novo designed cyclic peptide Authors: Wang, J, Rosenblatt, M.M, Suslick, K.S. Deposit date: 2003-05-15 Release date: 2003-12-09 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: De novo designed cyclic-peptide heme complexes Proc.Natl.Acad.Sci.USA, 100, 2003
7UWZ	NMR solution structure of the De novo designed small beta-barrel protein 33_bp_sh3 Descriptor: De novo designed small beta-barrel protein 33_bp_sh3 Authors: Peterson, F.C, Kim, D.E, Jensen, D.R, Saleem, A, Chow, C.M, Volkman, B.F, Baker, D. Deposit date: 2022-05-04 Release date: 2023-03-22 Method: SOLUTION NMR Cite: De novo design of small beta barrel proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
7UWY	NMR solution structure of the De novo designed small beta-barrel protein 29_bp_sh3 Descriptor: De novo designed small beta-barrel protein 29_bp_sh3 Authors: Peterson, F.C, Kim, D.E, Jensen, D.R, Saleem, A, Chow, C.M, Volkman, B.F, Baker, D. Deposit date: 2022-05-04 Release date: 2023-03-22 Method: SOLUTION NMR Cite: De novo design of small beta barrel proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
6X1K	Solution NMR structure of de novo designed TMB2.3 Descriptor: De novo designed transmembrane beta-barrel TMB2.3 Authors: Liang, B, Vorobieva, A.A, Chow, C.M, Baker, D, Tamm, L.K. Deposit date: 2020-05-19 Release date: 2021-02-17 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: De novo design of transmembrane beta barrels. Science, 371, 2021
6E5C	Solution NMR structure of a de novo designed double-stranded beta-helix Descriptor: De novo beta protein Authors: Marcos, E, Chidyausiku, T.M, McShan, A, Evangelidis, T, Nerli, S, Sgourakis, N, Tripsianes, K, Baker, D. Deposit date: 2018-07-19 Release date: 2018-11-07 Last modified: 2018-11-14 Method: SOLUTION NMR Cite: De novo design of a non-local beta-sheet protein with high stability and accuracy. Nat. Struct. Mol. Biol., 25, 2018
7M5T	Solution NMR structure of de novo designed protein 0515 Descriptor: De novo designed protein 0515 Authors: Ramelot, T.A, Hao, J, Baker, D, Montelione, G.T. Deposit date: 2021-03-24 Release date: 2021-12-15 Last modified: 2022-07-27 Method: SOLUTION NMR Cite: De novo protein design by deep network hallucination. Nature, 600, 2021

 

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