PDB: 1940 件ウェブページステータス検索Chemie searchBIRD

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7ZPL	Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook 分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7ZPM	Influenza A/H7N9 polymerase apo-protein dimer complex 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7XME	Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative 分子名称: (2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, IODIDE ION, Polymerase basic protein 2 著者 Zhang, Z. 登録日 2022-04-25 公開日 2023-05-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.521 Å) 主引用文献 Discovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region To Be Published
7UO7	SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO4	SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO9	SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOE	SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOB	SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7ZIU	Crystal structure of Ntaya virus NS5 polymerase domain 分子名称: Genome polyprotein, ZINC ION 著者 Krejcova, K, Klima, M, Boura, E. 登録日 2022-04-08 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of Ntaya virus NS5 polymerase domain To Be Published
7UMR	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-1 (trans-form) 分子名称: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-04-07 公開日 2022-10-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7XGC	Crystal structure of influenza polymerase acidic subunit N-terminal domain crystallized by ammonium sulfate with glycan 分子名称: MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION 著者 Guo, Y, Hoshino, T. 登録日 2022-04-04 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Influence of Glycan Agents on Protein Crystallization with Ammonium Sulfate Cryst.Growth Des., 2022
7UIG	Mediator-PIC Early (Mediator A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-02-15 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
7UIF	Mediator-PIC Early (Core B) 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-02-15 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
7UIO	Mediator-PIC Early (Composite Model) 分子名称: ALANINE, ASPARTIC ACID, DNA (37-MER), ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-03-01 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
7UI9	Core Mediator-PICearly (Copy A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-28 公開日 2023-02-15 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
7XD8	Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) 分子名称: GLYCEROL, NS5, RNA (30-mer), ... 著者 Wu, J, Wang, X, Gong, P. 登録日 2022-03-26 公開日 2022-12-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
7XD9	Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Wu, J, Wang, X, Gong, P. 登録日 2022-03-26 公開日 2022-12-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
7X6V	lymphocytic choriomeningitis virus polymerase- Matrix Z Protein Complex (LCMV L-Z Complex) 分子名称: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Liu, L, Lou, Z. 登録日 2022-03-08 公開日 2023-09-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
7X6S	lymphocytic choriomeningitis virus RNA-dependent RNA polymerase (LCMV-L protein) 分子名称: MANGANESE (II) ION, RNA-directed RNA polymerase L 著者 Liu, L, Lou, Z. 登録日 2022-03-08 公開日 2023-09-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
7Z4O	Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A 分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Pflug, A. 登録日 2022-03-04 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.412 Å) 主引用文献 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022
7Z43	Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Drncova, P. 登録日 2022-03-03 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.123 Å) 主引用文献 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022
7Z42	Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B 分子名称: DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Drncova, P. 登録日 2022-03-03 公開日 2022-05-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.418 Å) 主引用文献 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022
7Z2Z	Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A 分子名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... 著者 Nguyen, P.Q, Fernandez-Tornero, C. 登録日 2022-03-01 公開日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023
7Z30	Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.9 A (focus subunit C11 terminal Zn-ribbon in the funnel pore). 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Nguyen, P.Q, Fernandez-Tornero, C. 登録日 2022-03-01 公開日 2023-04-05 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023
7Z31	Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11, no C11 C-terminal Zn-ribbon in the funnel pore). 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Nguyen, P.Q, Huecas, S, Plaza-Pegueroles, A, Fernandez-Tornero, C. 登録日 2022-03-01 公開日 2023-04-05 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023

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