PDB: 1932 件ウェブページステータス検索Chemie searchBIRD

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7OJJ	Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK] 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-16 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7OE3	Apo-structure of Lassa virus L protein (well-resolved endonuclease) [APO-ENDO] 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-01 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7NK2	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core 分子名称: Nanobody8202, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.84 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NJ5	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core 分子名称: Nb8199 Core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-16 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.63 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NIS	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core 分子名称: Nanobody8192 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-13 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.96 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NJ3	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core 分子名称: Nanobody8196 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-15 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.48 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NIR	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core 分子名称: Nanobody8191 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-13 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NJ7	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core 分子名称: Nb8200 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-16 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.82 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
8ASD	Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2022-08-19 公開日 2023-01-18 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
3CJ5	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide, RNA-directed RNA polymerase 著者 Hendle, j. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CJ0	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 分子名称: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CIZ	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 分子名称: 2-amino-5-bromobenzoic acid, RNA-directed RNA polymerase, ZINC ION 著者 Hendle, j. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CJ3	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
7RE3	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RDX	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RDZ	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class 分子名称: ADENOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE2	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE0	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RDY	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE1	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
3CJ4	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: 4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Antonysamy, s.s. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
7NHC	1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b) 分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-10 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NIL	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core 分子名称: Nanobody8190 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-12 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.01 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NKC	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 分子名称: Nb8207, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (4.46 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NK8	1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core 分子名称: Nb8205, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... 著者 Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. 登録日 2021-02-17 公開日 2021-12-01 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (5.34 Å) 主引用文献 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022

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