PDB: 1932 件ウェブページステータス検索Chemie searchBIRD

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4ADP	HCV-J6 NS5B POLYMERASE V405I MUTANT 分子名称: RNA-DIRECTED RNA POLYMERASE 著者 Scrima, N, Bressanelli, S. 登録日 2012-01-02 公開日 2012-05-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86, 2012
2XI2	HCV-H77 NS5B Apo Polymerase 分子名称: RNA-directed RNA polymerase, SULFATE ION 著者 Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. 登録日 2010-06-25 公開日 2010-08-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
8C4S	Apo Hantaan virus polymerase core 分子名称: RNA-directed RNA polymerase L 著者 Durieux trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-01-04 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication. Nat Commun, 14, 2023
2R7Q	Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged) 分子名称: RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-09 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R7O	Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (N-terminal hexahistidine-tagged) 分子名称: RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-09 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
8K43	In situ structure of RNA-dependent RNA polymerase in full BAV particles 分子名称: RNA-directed RNA polymerase (Fragment), VP2 著者 Li, Z, Cao, S. 登録日 2023-07-17 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes. Nat Commun, 15, 2024
7VH3	Cryo-EM structure of Machupo virus polymerase L 分子名称: RNA-directed RNA polymerase L 著者 Ma, J, Zhang, S, Zhang, X. 登録日 2021-09-20 公開日 2021-09-29 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of Machupo virus polymerase in complex with matrix protein Z. Nat Commun, 12, 2021
7VH2	Cryo-EM structure of Machupo virus dimeric polymerase L 分子名称: RNA-directed RNA polymerase L 著者 Zhang, X, Ma, J, Zhang, S. 登録日 2021-09-20 公開日 2021-09-29 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (5.1 Å) 主引用文献 Structure of Machupo virus polymerase in complex with matrix protein Z. Nat Commun, 12, 2021
4ZPC	Coxsackievirus B3 Polymerase - A341G mutant 分子名称: RNA-dependent RNA polymerase 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
4ZP8	Coxsackievirus B3 Polymerase - F364L mutant 分子名称: RNA-dependent RNA polymerase 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.894 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
4ZP9	Coxsackievirus B3 Polymerase - F364I mutant 分子名称: RNA-dependent RNA polymerase 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
5Y3D	Structural insight into the interaction between RNA polymerase and VPg for norovirus replication 分子名称: RNA-dependent RNA polymerase, viral protein genome-linked (VPg) 著者 Kim, K.H, Lee, J.-H, Seok, J.H. 登録日 2017-07-28 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol, 9, 2018
3JA5	Genome and RdRp structure within the capsid of no-transcribing cypovirus 分子名称: RNA-dependent RNA polymerase 著者 Liu, H, Cheng, L. 登録日 2015-04-21 公開日 2015-10-28 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (12 Å) 主引用文献 Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus. Science, 349, 2015
6K32	RdRp complex 分子名称: 2'-O-methyladenosine 5'-(dihydrogen phosphate), 7-METHYLGUANOSINE, DIPHOSPHATE, ... 著者 Li, X.W. 登録日 2019-05-16 公開日 2019-11-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis. J.Mol.Biol., 432, 2020
4K4Y	Coxsackievirus B3 polymerase elongation complex (r2+1_form) 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, ACETATE ION, DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(DOC))-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4Z	Coxsackievirus B3 polymerase elongation complex (r2_Mg_form) 分子名称: MAGNESIUM ION, RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4X	Coxsackievirus B3 polymerase elongation complex (r2_form), rna 分子名称: GLYCEROL, MAGNESIUM ION, RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
7OM9	Thosea asigna virus RdRP domain 分子名称: RNA-dependent RNA polymerase 著者 Ferrero, D.S, Falqui, M, Verdaguer, N. 登録日 2021-05-21 公開日 2021-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Snapshots of a Non-Canonical RdRP in Action. Viruses, 13, 2021
7R0E	Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-02-01 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7R1F	Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-02-02 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7QTL	Influenza A/H7N9 polymerase elongation complex 分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... 著者 Cusack, S, Kouba, T. 登録日 2022-01-14 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.48 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
5PZM	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 3-[2-(4-FLUOROPHENYL)-3-(METHYLCARBAMOYL)-1-BENZOFURAN-5-YL]BENZOIC ACID 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 3-[2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-5-yl]benzoic acid, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZN	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-2-(4-FLUOROPHENYL)-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 5-[3-(tert-butylcarbamoyl)phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZO	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE C316N IN COMPLEX WITH 2-(4-FLUOROPHENYL)-N-METHYL-5-[3-({2-METHYL-1-OXO-1-[(1,3,4-THIADIAZOL-2-YL)AMINO]PROPAN-2-YL}CARBAMOYL)PHENYL]-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-(4-fluorophenyl)-N-methyl-5-[3-({2-methyl-1-oxo-1-[(1,3,4-thiadiazol-2-yl)amino]propan-2-yl}carbamoyl)phenyl]-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZL	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-({3-[1-(2-CYCLOPROPYLETHYL)-6-FLUORO-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL]-1,1-DIOXO-1,4-DIHYDRO-1LAMBDA~6~,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda~6~,2,4-benzothiadiazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017

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