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7D5Y
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Cystein protease domain from MARTX toxin
分子名称: GLYCEROL, MARTX
著者Kim, M.-H, Hwang, J, Choi, S.
登録日2020-09-28
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Cystein protease domain from MARTX toxin
To Be Published
3EEB
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BU of 3eeb by Molmil
Structure of the V. cholerae RTX cysteine protease domain
分子名称: INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION
著者Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C.
登録日2008-09-04
公開日2008-10-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
Science, 322, 2008
3PA8
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BU of 3pa8 by Molmil
Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor
分子名称: CALCIUM ION, INOSITOL HEXAKISPHOSPHATE, N-acetylglycyl-N-[(3S)-1-hydroxy-5-methyl-2-oxohexan-3-yl]-L-serinamide, ...
著者Lupardus, P.J, Garcia, K.C.
登録日2010-10-18
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.
Chem.Biol., 17, 2010
3PEE
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Structure of the C. difficile TcdB cysteine protease domain
分子名称: CALCIUM ION, INOSITOL HEXAKISPHOSPHATE, Toxin B
著者Lupardus, P.J, Garcia, K.C.
登録日2010-10-26
公開日2011-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Nat.Struct.Mol.Biol., 18, 2011
3FZY
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Crystal Structure of Pre-cleavage Form of Cysteine Protease Domain from Vibrio cholerae RtxA Toxin
分子名称: CHLORIDE ION, INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, ...
著者Shuvalova, L, Minasov, G, Prochazkova, K, Satchell, K.J.F, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2009-01-26
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites
J.Biol.Chem., 284, 2009
3GCD
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BU of 3gcd by Molmil
Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor
分子名称: INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ...
著者Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M.
登録日2009-02-21
公開日2009-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nat.Chem.Biol., 5, 2009
3HO6
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BU of 3ho6 by Molmil
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in clostridium difficile toxin A
分子名称: INOSITOL HEXAKISPHOSPHATE, Toxin A
著者Pruitt, R.N, Lacy, D.B.
登録日2009-06-01
公開日2009-06-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A.
J.Biol.Chem., 284, 2009
4R04
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BU of 4r04 by Molmil
Clostridium difficile Toxin A (TcdA)
分子名称: Toxin A, ZINC ION
著者Lacy, D.B, Spiller, B.W, Rutherford, S.A.
登録日2014-07-29
公開日2016-01-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.26 Å)
主引用文献Glucosyl Transferase Structure
Nat Microbiol, 2016
6EN3
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BU of 6en3 by Molmil
Crystal structure of full length EndoS from Streptococcus pyogenes in complex with G2 oligosaccharide.
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F2,Multifunctional-autoprocessing repeats-in-toxin, NICKEL (II) ION, ...
著者Trastoy, B, Klontz, E.H, Orwenyo, J, Marina, A, Wang, L.X, Sundberg, E.J, Guerin, M.E.
登録日2017-10-04
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.903 Å)
主引用文献Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.
Nat Commun, 9, 2018
7POG
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BU of 7pog by Molmil
High-resolution structure of native toxin A from Clostridioides difficile
分子名称: Toxin A, ZINC ION
著者Boesen, T, Joergensen, R, Aminzadeh, A, Engelbrecht Larsen, C.
登録日2021-09-08
公開日2021-12-08
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献High-resolution structure of native toxin A from Clostridioides difficile.
Embo Rep., 23, 2022
6OQ5
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BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
分子名称: 5D, 7F, E3, ...
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.87 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
7V1N
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BU of 7v1n by Molmil
Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI
分子名称: Isoform Beta of Tissue factor pathway inhibitor, Toxin B
著者Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L.
登録日2021-08-05
公開日2022-02-23
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
6AR6
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BU of 6ar6 by Molmil
Clostridioides difficile toxinB with DLD-4 darpin
分子名称: DLD-4 darpin, Toxin B
著者Zhang, J, Jiang, M.
登録日2017-08-21
公開日2018-08-22
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献Clostridioides difficile toxinB with DLD-4 darpin
To Be Published
8QEN
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BU of 8qen by Molmil
cryo-EM structure of apo Clostridioides difficile toxin B
分子名称: Toxin B, ZINC ION
著者Kinsolving, J, Bous, J, Structural Genomics Consortium (SGC)
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
8X2I
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BU of 8x2i by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its open conformation
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-11-09
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8X2H
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BU of 8x2h by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its closed conformation
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-11-09
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8JB5
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BU of 8jb5 by Molmil
The cryo-EM structure of Paeniclostridium sordellii lethal toxin (TcsL)
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-05-08
公開日2023-12-13
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8JHZ
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BU of 8jhz by Molmil
Cryo-EM structure of the TcsH-TMPRSS2 complex
分子名称: Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION
著者Zhou, R, Liang, T, Zhan, X.
登録日2023-05-25
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
Nat Commun, 15, 2024
8QEO
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BU of 8qeo by Molmil
cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B
分子名称: Frizzled-7, Toxin B, ZINC ION
著者Kinsolving, J, Bous, J.
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
著者Chen, P, Jin, R.
登録日2021-04-27
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
7N95
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BU of 7n95 by Molmil
state 1 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-16
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Q
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BU of 7n9q by Molmil
State 3 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N97
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State 2 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-17
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of the Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9R
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state 4 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9S
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TcdB and frizzled-2 CRD complex
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published

 

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