2RGS
| FC-fragment of monoclonal antibody IGG2B from Mus musculus | Descriptor: | Ig gamma-2B heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kolenko, P, Duskova, J, Skalova, T, Dohnalek, J, Hasek, J. | Deposit date: | 2007-10-05 | Release date: | 2008-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution Immunology, 126, 2008
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2WAH
| Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2) | Descriptor: | IG GAMMA-1 CHAIN C REGION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Crispin, M, Bowden, T.A, Coles, C.H, Harlos, K, Aricescu, A.R, Harvey, D.J, Stuart, D.I, Jones, E.Y. | Deposit date: | 2009-02-06 | Release date: | 2009-03-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Carbohydrate and Domain Architecture of an Immature Antibody Glycoform Exhibiting Enhanced Effector Functions J.Mol.Biol., 387, 2009
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2VB5
| Solution structure of W60G mutant of human beta2-microglobulin | Descriptor: | BETA-2-MICROGLOBULIN | Authors: | Esposito, G, Corazza, A, Rennella, E, Gumral, D, Mimmi, M.C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M, Bellotti, V. | Deposit date: | 2007-09-06 | Release date: | 2007-09-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Controlling Roles of Trp60 and Trp95 in Beta2-Microglobulin Function, Folding and Amyloid Aggregation Properties. J.Mol.Biol., 378, 2008
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2WQR
| The high resolution crystal structure of IgE Fc | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, IG EPSILON CHAIN C REGION, ... | Authors: | Dhaliwal, B, Sutton, B.J, Beavil, A.J. | Deposit date: | 2009-08-26 | Release date: | 2010-11-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri Nat.Struct.Mol.Biol., 18, 2011
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2VUO
| Crystal structure of the rabbit IgG Fc fragment | Descriptor: | AZIDE ION, FORMIC ACID, GLYCEROL, ... | Authors: | Girardi, E, Holdom, M.D, Davies, A.M, Sutton, B.J, Beavil, A.J. | Deposit date: | 2008-05-27 | Release date: | 2008-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Crystal Structure of Rabbit Igg-Fc. Biochem.J., 417, 2009
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2XKS
| Prion-like conversion during amyloid formation at atomic resolution | Descriptor: | BETA-2-MICROGLOBULIN | Authors: | Eichner, T, Kalverda, A.P, Thompson, G.S, Radford, S.E, Homans, S.W. | Deposit date: | 2010-07-12 | Release date: | 2011-02-16 | Last modified: | 2020-01-15 | Method: | SOLUTION NMR | Cite: | Conformational Conversion During Amyloid Formation at Atomic Resolution. Mol.Cell, 41, 2011
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7LFN
| Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fields, J.K, Sundberg, E.J. | Deposit date: | 2021-01-17 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
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7LF9
| Structure of Hyperglycosylated Human IgG1 Fc (Fc329) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc329), ... | Authors: | Fields, J.K, Sundberg, E.J. | Deposit date: | 2021-01-15 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
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7LF5
| Structure of Hyperglycosylated Human IgG1 Fc (Fc267) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267), alpha-L-fucopyranose, ... | Authors: | Fields, J.K, Sundberg, E.J. | Deposit date: | 2021-01-15 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
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7LBL
| Structure of Human IgG1 Fc | Descriptor: | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Fields, J.K, Sundberg, E.J. | Deposit date: | 2021-01-08 | Release date: | 2021-01-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
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7NMO
| Crystal structure of beta-2-microglobulin D76A mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMR
| Crystal structure of beta-2-microglobulin D76S mutant | Descriptor: | Beta-2-microglobulin, GLYCEROL | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMT
| Crystal structure of beta-2-microglobulin D76G mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMC
| Crystal structure of beta-2-microglobulin D76E mutant | Descriptor: | Beta-2-microglobulin, GLYCEROL, TRIETHYLENE GLYCOL | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMV
| Crystal structure of beta-2-microglobulin D76Q mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMY
| Crystal structure of beta-2-microglobulin D76Y mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NN5
| Crystal structure of beta-2-microglobulin D76K mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-24 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.242 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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1YEH
| STRUCTURE OF IGG2A FAB FRAGMENT | Descriptor: | FAB FRAGMENT, ZINC ION | Authors: | Gigant, B, Knossow, M. | Deposit date: | 1997-05-29 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release. Proc.Natl.Acad.Sci.USA, 94, 1997
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7NUI
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7MXI
| IgE-Fc in complex with DARPins E2_79 and E3_53 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IgE Inhibitor E2_79, DARPin E3_53, ... | Authors: | Pennington, L.F, Jardetzky, T.J. | Deposit date: | 2021-05-19 | Release date: | 2021-07-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J.Allergy Clin.Immunol., 148, 2021
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1YEC
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1YEF
| STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE | Descriptor: | IGG2A FAB FRAGMENT, PARA-NITROBENZYL GLUTARYL GLYCINIC ACID, ZINC ION | Authors: | Gigant, B, Knossow, M. | Deposit date: | 1997-05-29 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release. Proc.Natl.Acad.Sci.USA, 94, 1997
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1YED
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1YEG
| STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT | Descriptor: | ACETATE ION, IGG2A FAB FRAGMENT, PARANITROBENZYL ALCOHOL, ... | Authors: | Gigant, B, Knossow, M. | Deposit date: | 1997-05-29 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release. Proc.Natl.Acad.Sci.USA, 94, 1997
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1YEE
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