7MXI

IgE-Fc in complex with DARPins E2_79 and E3_53

Summary for 7MXI

Entry DOI	10.2210/pdb7mxi/pdb
Descriptor	IgE Fc, DARPin E3_53, Anti-IgE Inhibitor E2_79, ... (5 entities in total)
Functional Keywords	ige, darpin, allergy, inhibitor, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	125455.18
Authors	Pennington, L.F.,Jardetzky, T.J. (deposition date: 2021-05-19, release date: 2021-07-28, Last modification date: 2023-10-18)
Primary citation	Pennington, L.F.,Gasser, P.,Brigger, D.,Guntern, P.,Eggel, A.,Jardetzky, T.S. Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J.Allergy Clin.Immunol., 148:1049-1060, 2021 Cited by PubMed: 33991582 DOI: 10.1016/j.jaci.2021.03.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation