7MXI

IgE-Fc in complex with DARPins E2_79 and E3_53

Summary for 7MXI

• Entry DOI: 10.2210/pdb7mxi/pdb
• Descriptor: IgE Fc, DARPin E3_53, Anti-IgE Inhibitor E2_79, ... (5 entities in total)
• Functional Keywords: ige, darpin, allergy, inhibitor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 125455.18

Authors

Pennington, L.F.,Jardetzky, T.J. (deposition date: 2021-05-19, release date: 2021-07-28, Last modification date: 2024-10-23)

Primary citation

Pennington, L.F.,Gasser, P.,Brigger, D.,Guntern, P.,Eggel, A.,Jardetzky, T.S.
Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.
J.Allergy Clin.Immunol., 148:1049-1060, 2021

PubMed Abstract: Anaphylaxis represents one of the most severe and fatal forms of allergic reactions. Like most other allergies, it is caused by activation of basophils and mast cells by allergen-mediated cross-linking of IgE bound to its high-affinity receptor, FcεRI, on the cell surface. The systemic release of soluble mediators induces an inflammatory cascade, rapidly causing symptoms with peak severity in minutes to hours after allergen exposure. Primary treatment for anaphylaxis consists of immediate intramuscular administration of adrenaline.

PubMed: 33991582
DOI: 10.1016/j.jaci.2021.03.050

Experimental method

X-RAY DIFFRACTION (2.8 Å)