2RGS

FC-fragment of monoclonal antibody IGG2B from Mus musculus

Summary for 2RGS

• Entry DOI: 10.2210/pdb2rgs/pdb
• Descriptor: Ig gamma-2B heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: fc-fragment, immunoglobulin, glycosylation, immune system
• Biological source: Mus musculus (mouse)
• Cellular location: Isoform 1: Cell membrane; Single-pass membrane protein (Potential). Isoform 2: Secreted: P01867
• Total number of polymer chains: 2
• Total formula weight: 52312.55

Authors

Kolenko, P.,Duskova, J.,Skalova, T.,Dohnalek, J.,Hasek, J. (deposition date: 2007-10-05, release date: 2008-10-07, Last modification date: 2023-08-30)

• Primary citation: Kolenko, P.,Dohnalek, J.,Duskova, J.,Skalova, T.,Collard, R.,Hasek, J.; New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution; Immunology, 126:378-385, 2008; PubMed: 18783468; DOI: 10.1111/j.1365-2567.2008.02904.x

Experimental method

X-RAY DIFFRACTION (2.13 Å)