PDB: 69 件ウェブページステータス検索Chemie searchBIRD

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8IMA	Filament structure of GAC with phosphate 分子名称: Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION 著者 Guo, C.J, Liu, J.L. 登録日 2023-03-06 公開日 2024-04-10 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for activation and filamentation of glutaminase. Cell Res., 34, 2024
8IMB	Filament interface structure of GAC with phosphate 分子名称: Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION 著者 Guo, C.J, Liu, J.L. 登録日 2023-03-06 公開日 2024-04-10 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for activation and filamentation of glutaminase. Cell Res., 34, 2024
8JUB	Crystal structure of glutaminase C in complex with compound 27 分子名称: 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial 著者 Wang, X, Hanyu, S, Tingting, D. 登録日 2023-06-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
8JUE	Crystal structure of glutaminase C in complex with compound 11 分子名称: 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 著者 Wang, X, Hanyu, S, Tingting, D. 登録日 2023-06-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
5HL1	Crystal structure of glutaminase C in complex with inhibitor CB-839 分子名称: 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2016-01-14 公開日 2016-08-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C To Be Published
5I94	Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019 分子名称: 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R. 登録日 2016-02-19 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.983 Å) 主引用文献 Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
3UNW	Crystal Structure of Human GAC in Complex with Glutamate 分子名称: GLUTAMIC ACID, Glutaminase kidney isoform, mitochondrial 著者 DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wie, W, Hurov, J. 登録日 2011-11-16 公開日 2011-12-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry, 50, 2011
3UO9	Crystal Structure of Human GAC in Complex with Glutamate and BPTES 分子名称: GLYCEROL, Glutaminase kidney isoform, mitochondrial, ... 著者 DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wei, W, Hurov, J.B. 登録日 2011-11-16 公開日 2011-12-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry, 50, 2011
6UJG	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-03 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UMD	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UME	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UMC	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6ULJ	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-08 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00045 To Be Published
6UMF	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UK6	Crystal structure of human GAC in complex with inhibitor UPGL00018 分子名称: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-04 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00018 To Be Published
6UKB	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-04 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00020 To Be Published
6UJM	Crystal structure of human GAC in complex with inhibitor UPGL00013 分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-03 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00013 To Be Published
6ULA	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-07 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00030 To Be Published
6UL9	Crystal structure of human GAC in complex with inhibitor UPGL00023 分子名称: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q.Q, Cerione, R.A. 登録日 2019-10-07 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published

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