PDB: 159 resultsInfo pagesStatus searchChemie searchBIRD

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7YYJ	Tetragonal crystal structure of YTHDF1 YTH domain (544AVV546 mutant) Descriptor: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-18 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YZ8	Triclinic crystal structure of YTHDF1 YTH domain (544AVV546 mutant) Descriptor: THIOCYANATE ION, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-19 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YYE	Orthorombic crystal structure of YTHDF1 YTH domain (G459N mutant) form I Descriptor: 1,2-ETHANEDIOL, MALONIC ACID, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-17 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
6YKI	Crystal structure of YTHDC1 with compound DHU_DC1_092 Descriptor: SULFATE ION, YTHDC1, ~{N}-ethyl-2-[(2~{S},5~{R})-5-methyl-2-phenyl-morpholin-4-yl]ethanamine Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKZ	Crystal structure of YTHDC1 with compound DHU_DC1_234 Descriptor: SULFATE ION, YTHDC1, ~{N}-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKE	Crystal structure of YTHDC1 with compound DHU_DC1_038 Descriptor: (2~{R})-2-(3-fluorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YL0	Crystal structure of YTHDC1 with compound T_96 Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of YTHDC1 with compound T_96 To Be Published
6YL9	Crystal structure of YTHDC1 with compound DHU_DC1_085 Descriptor: 3-[(2~{R},5~{S})-2-(2,5-dimethylphenyl)-5-methyl-morpholin-4-yl]propane-1-sulfonamide, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNK	Crystal structure of YTHDC1 with compound DHU_DC1_068 Descriptor: 6-[[furan-2-ylmethyl(methyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNN	Crystal structure of YTHDC1 with compound DHU_DC1_135 Descriptor: 6-[[(2-chloranyl-6-fluoranyl-phenyl)methyl-methyl-amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6YOQ	Crystal structure of YTHDC1 with compound VVR_DC1_002 Descriptor: 6-methyl-~{N}-[2-(methylsulfonylamino)ethyl]-2-oxidanylidene-3~{H}-pyridine-3-carboxamide, SULFATE ION, YTHDC1 Authors: von Roten, V, Bedi, R.K, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNJ	Crystal structure of YTHDC1 with compound DHU_DC1_046 Descriptor: (2~{R})-2-(2-chlorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNM	Crystal structure of YTHDC1 with compound DHU_DC1_096 Descriptor: 1-[(2~{R},5~{S})-2-(3-chlorophenyl)-5-methyl-morpholin-4-yl]-3-methoxy-propan-2-ol, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YKJ	Crystal structure of YTHDC1 with compound DHU_DC1_125 Descriptor: SULFATE ION, YTHDC1, ~{N}-methyl-4-(methylamino)pyridine-2-carboxamide Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNI	Crystal structure of YTHDC1 with compound DHU_DC1_036 Descriptor: (2~{R},3~{R})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-13 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNL	Crystal structure of YTHDC1 with compound DHU_DC1_078 Descriptor: 3-[(2~{R})-5,5-dimethyl-2-phenyl-morpholin-4-yl]-~{N}-(methylcarbamoyl)propanamide, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNP	Crystal structure of YTHDC1 with compound T96C1 Descriptor: CHLORIDE ION, SULFATE ION, YTHDC1, ... Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YL8	Crystal structure of YTHDC1 with compound DHU_DC1_011 Descriptor: (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-06 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
6YNO	Crystal structure of YTHDC1 with compound DHU_DC1_139 Descriptor: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-14 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
6YM2	Crystal structure of YTHDC1 with compound ADO_AC_25 Descriptor: SULFATE ION, YTHDC1, ~{N},9-dimethylpurin-6-amine Authors: Bedi, R.K, Li, Y, Dolbois, A, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-07 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of YTHDC1 with compound ADO_AC_25 To Be Published
6YM8	Crystal structure of YTHDC1 with compound YLI_DC1_002 Descriptor: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Li, Y, Wiedmer, L, Caflisch, A. Deposit date: 2020-04-07 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of YTHDC1 with compound YLI_DC1_002 To Be Published
6WEA	YTH domain of human YTHDC1 with a 10mer Oligo Containing N6mA Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*TP*C)-3'), SODIUM ION, ... Authors: Horton, J.R, Cheng, X. Deposit date: 2020-04-01 Release date: 2020-07-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res., 48, 2020
6ZD9	Crystal structure of YTHDC1 apo purified using GST tag Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1 Authors: Bedi, R.K, Caflisch, A. Deposit date: 2020-06-14 Release date: 2020-07-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
8Q2Q	Crystal structure of YTHDC1 in complex with Compound 2b (YL_32) Descriptor: 2-chloranyl-~{N},9-dimethyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Li, Y, Caflisch, A. Deposit date: 2023-08-03 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 2b (YL_32) To Be Published
8Q2W	Crystal structure of YTHDC1 in complex with Compound 8 (CS_01) Descriptor: 2-chloranyl-9-(cyclohexylmethyl)-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-03 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 8 (CS_01) To Be Published

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