6YKZ
Crystal structure of YTHDC1 with compound DHU_DC1_234
Summary for 6YKZ
Entry DOI | 10.2210/pdb6ykz/pdb |
Descriptor | YTHDC1, ~{N}-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ythdc1, m6a, complex, inhibitor, rna binding protein |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 43033.21 |
Authors | Bedi, R.K.,Huang, D.,Wiedmer, L.,Caflisch, A. (deposition date: 2020-04-06, release date: 2020-07-15, Last modification date: 2024-01-24) |
Primary citation | Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A. Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5:100057-, 2022 Cited by DOI: 10.1016/j.ejmcr.2022.100057PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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