6YKZ

Crystal structure of YTHDC1 with compound DHU_DC1_234

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue OW8 A 601

Chain	Residue
A	ASN363
A	HOH716
A	HOH748
A	HOH764
A	ASN367
A	TRP377
A	SER378
A	TRP428
A	PRO431
A	MET434
A	LEU439
A	ASP476

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 602

Chain	Residue
A	GLY344
A	SER346
A	LYS347
A	HOH731
A	HOH743
A	HOH847

---

site_id	AC3
Number of Residues	11
Details	binding site for residue SO4 A 603

Chain	Residue
A	TRP465
A	GLN478
A	GLU479
A	HOH704
A	HOH758
A	HOH762
A	HOH785
A	HOH796
A	HOH853
B	GLY344
B	LYS347

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG404
A	ARG475
A	ASP476
A	HOH723
A	HOH759

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 605

Chain	Residue
A	HIS420
A	HIS421

---

site_id	AC6
Number of Residues	8
Details	binding site for residue OW8 B 601

Chain	Residue
B	ASN363
B	ASN367
B	TRP377
B	SER378
B	TRP428
B	ASP476
B	HOH734
B	HOH793

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 B 602

Chain	Residue
B	ARG451
B	GLU452
B	HOH761
B	HOH775
B	HOH783
B	HOH788
B	HOH807
B	HOH810

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 B 603

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451
B	HOH736
B	HOH767
B	HOH897

---

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 B 604

Chain	Residue
B	LYS361
B	ARG404
B	GLU405
B	ARG475
B	HOH702
B	HOH727

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 605

Chain	Residue
B	ARG475
B	ASP476
B	HOH757
B	HOH766
B	HOH825

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---