PDB: 153 resultsInfo pagesStatus searchChemie searchBIRD

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6FVB	Structure of Lph2 , a novel bidirectional nuclear transport receptor in S. cerevisiae Descriptor: Importin beta-like protein KAP120 Authors: Vera Rodriguez, A, Huyton, T, Gorlich, D. Deposit date: 2018-03-01 Release date: 2019-09-11 Method: X-RAY DIFFRACTION (3.297 Å) Cite: Structure of Lph2 , a novel bidirectional nuclear transport receptor in S. cerevisiae To Be Published
6AHO	Crystal structure of Kap114p Descriptor: Importin subunit beta-5 Authors: Liao, C.C, Shankar, S, Ahmed, G.R, Hsia, K.C. Deposit date: 2018-08-20 Release date: 2019-10-23 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression under saline stress. Embo Rep., 21, 2020
4BSN	Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.1A Descriptor: EXPORTIN-1 Authors: Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. Deposit date: 2013-06-11 Release date: 2013-07-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
4XRI	Crystal Structure of Importin Beta in an Ammonium Sulfate Condition Descriptor: GLYCEROL, Putative uncharacterized protein, SULFATE ION Authors: Tauchert, M.J, Neumann, P, Ficner, R, Dickmanns, A. Deposit date: 2015-01-21 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Impact of the crystallization condition on importin-beta conformation. Acta Crystallogr D Struct Biol, 72, 2016
4XRK	Crystal Structure of Importin Beta in a Polyethylene Glycol Condition Descriptor: Importin Beta Authors: Tauchert, M.J, Neumann, P, Ficner, R, Dickmanns, A. Deposit date: 2015-01-21 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Impact of the crystallization condition on importin-beta conformation. Acta Crystallogr D Struct Biol, 72, 2016
4BSM	Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.5A Descriptor: EXPORTIN-1 Authors: Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. Deposit date: 2013-06-10 Release date: 2013-07-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
1GCJ	N-TERMINAL FRAGMENT OF IMPORTIN-BETA Descriptor: IMPORTIN BETA Authors: Lee, S.J, Imamoto, N, Sakai, H, Nakagawa, A, Kose, S, Koike, M, Yamamoto, M, Kumasaka, T, Yoneda, Y, Tsukihara, T. Deposit date: 2000-07-31 Release date: 2000-10-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport. J.Mol.Biol., 302, 2000
3GB8	Crystal structure of CRM1/Snurportin-1 complex Descriptor: Exportin-1, Snurportin-1 Authors: Dong, X, Biswas, A, Suel, K.E, Jackson, L.K, Martinez, R, Gu, H, Chook, Y.M. Deposit date: 2009-02-19 Release date: 2009-03-31 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature, 458, 2009
3VYC	Crystal structure of unliganded Saccharomyces cerevisiae CRM1 (Xpo1p) Descriptor: Exportin-1 Authors: Saito, N, Matsuura, Y. Deposit date: 2012-09-22 Release date: 2012-11-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A 2.1- angstrom -resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition J.Mol.Biol., 425, 2013
3ZKV	Importin13 cytosolic state Descriptor: CADMUS Authors: Gruenwald, M, Lazzaretti, D, Bono, F. Deposit date: 2013-01-24 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Basis for the Nuclear Export Activity of Importin13. Embo J., 32, 2013
5YU7	CRYSTAL STRUCTURE OF EXPORTIN-5 Descriptor: Exportin-5 Authors: Yamazawa, R, Jiko, C, Lee, S.J, Yamashita, E. Deposit date: 2017-11-20 Release date: 2018-08-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.301 Å) Cite: Structural Basis for Selective Binding of Export Cargoes by Exportin-5 Structure, 26, 2018
5OWU	Kap95:Nup1 complex Descriptor: Importin subunit beta-1, Nucleoporin NUP1 Authors: Stewart, M. Deposit date: 2017-09-04 Release date: 2017-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p. J. Mol. Biol., 349, 2005
1WA5	Structure of the Cse1:Imp-alpha:RanGTP complex Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin alpha re-exporter, ... Authors: Stewart, M. Deposit date: 2004-10-23 Release date: 2004-12-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the assembly of a nuclear export complex. Nature, 432, 2004
1IBR	COMPLEX OF RAN WITH IMPORTIN BETA Descriptor: GTP-binding nuclear protein RAN, Importin beta-1 subunit, MAGNESIUM ION, ... Authors: Vetter, I.R, Arndt, A, Kutay, U, Goerlich, D, Wittinghofer, A. Deposit date: 1999-05-14 Release date: 1999-06-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural view of the Ran-Importin beta interaction at 2.3 A resolution Cell(Cambridge,Mass.), 97, 1999
6TVO	Human CRM1-RanGTP in complex with Leptomycin B Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Shaikhqasem, A, Ficner, R. Deposit date: 2020-01-10 Release date: 2020-07-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.201 Å) Cite: Characterization of Inhibition Reveals Distinctive Properties for Human andSaccharomyces cerevisiaeCRM1. J.Med.Chem., 63, 2020
2H4M	Karyopherin Beta2/Transportin-M9NLS Descriptor: Heterogeneous nuclear ribonucleoprotein A1, Transportin-1 Authors: Chook, Y.M, Cansizoglu, A.E. Deposit date: 2006-05-24 Release date: 2006-10-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell(Cambridge,Mass.), 126, 2006
2BKU	Kap95p:RanGTP complex Descriptor: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... Authors: Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. Deposit date: 2005-02-21 Release date: 2005-05-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
7L5E	Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-12-21 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.944 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
7YPZ	Zafirlukast in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-08-05 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
4OO6	Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) Descriptor: RNA-binding protein 39, Transportin-1 Authors: Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) Deposit date: 2014-01-30 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) to be published
7B51	Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528 Descriptor: BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Shaikhqasem, A, Ficner, R. Deposit date: 2020-12-03 Release date: 2021-03-10 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP. Acta Crystallogr.,Sect.F, 77, 2021
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8SGH	Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1 Authors: Gonzalez, A, Fung, H.Y.J, Chook, Y.M. Deposit date: 2023-04-12 Release date: 2023-06-14 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.17 Å) Cite: A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure, 31, 2023
3GJX	Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Monecke, T, Guettler, T, Neumann, P, Dickmanns, A, Goerlich, D, Ficner, R. Deposit date: 2009-03-09 Release date: 2009-05-26 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP. Science, 2009
1Z3H	The exportin Cse1 in its cargo-free, cytoplasmic state Descriptor: Importin alpha re-exporter, MAGNESIUM ION Authors: Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E. Deposit date: 2005-03-12 Release date: 2005-05-10 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.1 Å) Cite: The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding Mol.Cell, 18, 2005

 

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