PDB: 205 件ウェブページステータス検索Chemie searchBIRD

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5WN1	APE1 exonuclease product complex 分子名称: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5WN5	APE1 exonuclease substrate complex with a C/T mismatch and Mn2+ 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DV3))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5WN4	APE1 exonuclease substrate complex with a C/T mismatch 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5WN0	APE1 exonuclease substrate complex with a C/G match 分子名称: DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5WN2	APE1 exonuclease substrate complex with phosphoglycolate 分子名称: 1,2-ETHANEDIOL, 2-PHOSPHOGLYCOLIC ACID, CALCIUM ION, ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.288 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5WN3	APE1 F266A exonuclease substrate complex with a C/T mismatch 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
5TVP	SUMO2 bound to Mouse Tdp2 catalytic domain with a 5'-phosphorylated DNA ternary complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-11-09 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.399 Å) 主引用文献 ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Science, 357, 2017
5TVQ	Mouse Tdp2 catalytic domain bound to SUMO2 分子名称: ACETATE ION, CALCIUM ION, Small ubiquitin-related modifier 2, ... 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-11-09 公開日 2017-09-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Science, 357, 2017
5UVG	Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound 分子名称: CALCIUM ION, Sphingomyelin phosphodiesterase 3,Sphingomyelin phosphodiesterase 3 著者 Airola, M.V, Guja, K.E, Garcia-Diaz, M, Hannun, Y.A. 登録日 2017-02-20 公開日 2017-06-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5EWT	Crystal structure of ExoIII endonuclease from Sulfolobus islandicus 分子名称: Exodeoxyribonuclease III Xth 著者 Yan, Z, Yuan, Z.L, Gu, L.C, Shen, Y.L. 登録日 2015-11-21 公開日 2016-11-23 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of ExoIII endonuclease from Sulfolobus islandicus To Be Published
5DV4	Crystal structure of human CNOT6L in complex with neomycin 分子名称: CCR4-NOT transcription complex subunit 6-like, NEOMYCIN, SULFATE ION 著者 Zhang, Q, Bartlam, M. 登録日 2015-09-21 公開日 2016-10-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for inhibition of the deadenylase activity of human CNOT6L Febs Lett., 590, 2016
5CFE	Bacillus subtilis AP endonuclease ExoA 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Exodeoxyribonuclease 著者 Morera, S, Vigouroux, A. 登録日 2015-07-08 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA. Biochimie, 128-129, 2016
5CFG	C2 crystal form of APE1 with Mg2+ 分子名称: DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION 著者 Morera, S, Vigouroux, A. 登録日 2015-07-08 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA. Biochimie, 128-129, 2016
5DV2	Crystal structure of human CNOT6L in complex with cytidine-5'-monophosphate 分子名称: CCR4-NOT transcription complex subunit 6-like, CYTIDINE-5'-MONOPHOSPHATE 著者 Zhang, Q, Bartlam, M. 登録日 2015-09-21 公開日 2016-05-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural basis for inhibition of the deadenylase activity of human CNOT6L Febs Lett., 590, 2016
5J3S	Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor 分子名称: 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, Tyrosyl-DNA phosphodiesterase 2 著者 Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. 登録日 2016-03-31 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
5J42	Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, 10-(4-hydroxyphenyl)-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, GLYCEROL, ... 著者 Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. 登録日 2016-03-31 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
5J3P	Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 分子名称: GLYCEROL, MAGNESIUM ION, Tyrosyl-DNA phosphodiesterase 2 著者 Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. 登録日 2016-03-31 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
5J3Z	Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, ACETATE ION, ... 著者 Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. 登録日 2016-03-31 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473, 2016
5HT2	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with 1-N6-etheno-adenine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA, ... 著者 Schellenberg, M.J, Vilas, C.K, Williams, R.S. 登録日 2016-01-26 公開日 2016-04-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INP	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mn2+ complex 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), MANGANESE (II) ION, ... 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.947 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INO	Human Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex 分子名称: DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), SULFATE ION, Tyrosyl-DNA phosphodiesterase 2 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.205 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INN	Mouse Tdp2 D358N protein, apo state with increased disorder amongst variable DNA-binding grasp conformations 分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ... 著者 Schellenberg, M.J, Appel, C.D, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INL	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*AP*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... 著者 Schellenberg, M.J, Vilas, C.K, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INQ	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Ca2+ complex 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.848 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5INK	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*(3DR)P*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... 著者 Schellenberg, M.J, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016

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