PDB: 74 件ウェブページステータス検索Chemie searchBIRD

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7JFY	GAS41 YEATS domain in complex with 5 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, N-(5-{3-[(2S)-1,3-thiazolidin-2-yl]azetidine-1-carbonyl}thiophen-2-yl)-L-prolinamide, ... 著者 Linhares, B.M, Listunov, D, Winkler, A, Grembecka, J, Cierpicki, T. 登録日 2020-07-17 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.100557 Å) 主引用文献 GAS41 YEATS domain in complex with 5 To Be Published
7F4A	Crystal structure of Taf14 YEATS domain in complex with H3K9bz peptide 分子名称: Histone H3, Transcription initiation factor TFIID subunit 14 著者 Wang, D, Yan, F, Yong, C. 登録日 2021-06-18 公開日 2022-03-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7F5M	Crystal structure of Sas5 YEATS domain in complex with H3K27bz peptide 分子名称: GLYCEROL, LYS-GLN-LEU-ALA-SER-LYS-ALA-ALA-ARG-LBZ-SER-ALA-PRO-SER-THR-GLY-GLY-VAL-LYS-TYR, Something about silencing protein 5 著者 Wang, D, Yan, F, Chen, Y. 登録日 2021-06-22 公開日 2022-03-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7E7C	Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 分子名称: 1,2-ETHANEDIOL, Histone H3K27ac(24-27) peptide, IODIDE ION, ... 著者 Li, Y, Li, H. 登録日 2021-02-25 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 To Be Published
7EIF	Crystal structure of GAS41 YEATS domain 分子名称: GLYCEROL, YEATS domain-containing protein 4 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
7EIC	Crystal structure of AF9 YEATS domain in complex with H4K5acK8ac peptide 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Histone H4, ... 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EID	Crystal structure of AF9 YEATS domain in complex with H4K8acK12ac peptide 分子名称: GLYCEROL, Histone H4, Protein AF-9 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EIE	Crystal structure of YEATS2 YEATS domain 分子名称: GLYCEROL, YEATS domain-containing protein 2 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7VKH	Crystal structure of AF9 YEATS domain in complex with hit 2 分子名称: GLYCEROL, Protein AF-9, ~{N}-(3-azanyl-4-chloranyl-phenyl)-2-methoxy-ethanamide 著者 Liu, Y, Ruan, K. 登録日 2021-09-30 公開日 2022-10-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Fragment-Based Discovery of AF9 YEATS Domain Inhibitors. Int J Mol Sci, 23, 2022
7VKG	Crystal structure of AF9 YEATS domain in complex with Compound 10 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Protein AF-9, ... 著者 Liu, Y, Ruan, K. 登録日 2021-09-29 公開日 2022-10-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Fragment-Based Discovery of AF9 YEATS Domain Inhibitors. Int J Mol Sci, 23, 2022
8DKB	Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b 分子名称: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4 著者 Dias, J.M, Byrnes, L.J, Varghese, A.H. 登録日 2022-07-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J.Med.Chem., 66, 2023
7X88	Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27 分子名称: CITRIC ACID, Histone H3K27ac(24-27) peptide, Protein ENL 著者 Li, Y.Y, Li, H.T. 登録日 2022-03-11 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X8F	Crystal structure of ENL T4 mutant YEATS domain in complex with histone H3 acetylation at K27 分子名称: CHLORIDE ION, H3K27ac(24-27) peptide, Protein ENL 著者 Li, Y, Peng, B, Li, H. 登録日 2022-03-12 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X8B	Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27 分子名称: H3K27ac(24-27) peptide, Protein ENL 著者 Li, Y, Peng, B, Li, H. 登録日 2022-03-11 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X8G	Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27 分子名称: H3K27ac(24-27) peptide, Protein ENL 著者 Li, Y, Peng, B, Li, H. 登録日 2022-03-12 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
8I60	Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr 分子名称: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ... 著者 Konuma, T, Zhou, M.-M. 登録日 2023-01-26 公開日 2023-07-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell, 83, 2023
8IIZ	Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K27ac peptide 分子名称: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ... 著者 Kikuchi, M, Umehara, T. 登録日 2023-02-24 公開日 2023-11-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8IIY	Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide 分子名称: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ... 著者 Kikuchi, M, Umehara, T. 登録日 2023-02-24 公開日 2023-11-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8IJ0	Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide 分子名称: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ... 著者 Kikuchi, M, Umehara, T. 登録日 2023-02-24 公開日 2023-11-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8PJ7	MLLT3 in complex with compound PFI-6 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. 登録日 2023-06-22 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
8PJI	MLLT1 in complex with compound 10a 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Protein ENL, ... 著者 Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. 登録日 2023-06-23 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
8X1C	Structure of nucleosome-bound SRCAP-C in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of nucleosome-bound SRCAP-C in the ADP-bound state To Be Published
8X15	Structure of nucleosome-bound SRCAP-C in the apo state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of nucleosome-bound SRCAP-C in the apo state To Be Published
8X19	Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state To Be Published

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