PDB: 74 resultsInfo pagesStatus searchChemie searchBIRD

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7X8G	Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27 Descriptor: H3K27ac(24-27) peptide, Protein ENL Authors: Li, Y, Peng, B, Li, H. Deposit date: 2022-03-12 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
8I60	Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr Descriptor: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ... Authors: Konuma, T, Zhou, M.-M. Deposit date: 2023-01-26 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell, 83, 2023
6T1I	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 1 Descriptor: 1,2-ETHANEDIOL, 4-(4-ethanoylphenyl)-~{N}-[(6-methoxypyridin-3-yl)methyl]piperazine-1-carboxamide, Protein ENL Authors: Chaikuad, A, Heidenreich, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-10-04 Release date: 2019-11-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
8IJ0	Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide Descriptor: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ... Authors: Kikuchi, M, Umehara, T. Deposit date: 2023-02-24 Release date: 2023-11-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.52 Å) Cite: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
6T1J	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 2 Descriptor: 1,2-ETHANEDIOL, Protein ENL, ~{N}-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-4-thiophen-2-ylcarbonyl-piperazine-1-carboxamide Authors: Chaikuad, A, Heidenreich, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-10-04 Release date: 2019-11-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
6T1M	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 4 Descriptor: 1,2-ETHANEDIOL, 4-cyano-~{N}-[2-(piperidin-1-ylmethyl)-1~{H}-benzimidazol-5-yl]benzamide, Protein ENL Authors: Chaikuad, A, Heidenreich, D, Moustakim, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-10-04 Release date: 2019-11-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
6T1O	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 6 Descriptor: 1,2-ETHANEDIOL, 4-iodanyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, Protein ENL Authors: Chaikuad, A, Heidenreich, D, Moustakim, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-10-04 Release date: 2019-11-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
5HJB	AF9 YEATS in complex with histone H3 Crotonylation at K9 Descriptor: Protein AF-9, peptide of Histone H3.1 Authors: Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. Deposit date: 2016-01-12 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain Mol.Cell, 62, 2016
5HJD	AF9 YEATS in complex with histone H3 Crotonylation at K18 Descriptor: COPPER (II) ION, Protein AF-9, SULFATE ION, ... Authors: Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. Deposit date: 2016-01-13 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.806 Å) Cite: Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Mol.Cell, 62, 2016
5J9S	ENL YEATS in complex with histone H3 acetylation at K27 Descriptor: H3K27ac peptide from Histone H3.1, Protein ENL, SULFATE ION Authors: Li, Y, Li, H. Deposit date: 2016-04-11 Release date: 2017-03-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.702 Å) Cite: ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia Nature, 543, 2017
5IOK	Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr Descriptor: (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14 Authors: Andrews, F.H, Kuateladze, T.G. Deposit date: 2016-03-08 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.22 Å) Cite: The Taf14 YEATS domain is a reader of histone crotonylation. Nat.Chem.Biol., 12, 2016
5IQL	Crystal structure of YEATS2 YEATS bound to H3K27cr peptide Descriptor: Histone H3.1, YEATS domain-containing protein 2 Authors: Li, H, Zhao, D, Guan, H. Deposit date: 2016-03-11 Release date: 2016-07-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: YEATS2 is a selective histone crotonylation reader. Cell Res., 26, 2016
5XTZ	Crystal structure of GAS41 YEATS bound to H3K27ac peptide Descriptor: ACETATE ION, THR-LYS-ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, YEATS domain-containing protein 4 Authors: Li, H.T, Zhao, D. Deposit date: 2017-06-21 Release date: 2018-06-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.105 Å) Cite: Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell Discov, 4, 2018
5Y8V	Crystal structure of GAS41 Descriptor: MAGNESIUM ION, YEATS domain-containing protein 4 Authors: Wang, Y, Hao, Q. Deposit date: 2017-08-21 Release date: 2018-04-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5WYI	The Yaf9 YEATS domain Recognizing H3K122suc Peptide Descriptor: (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ILE-MET-PRO-LYS-ASP-ILE-GLN-LEU, SUCCINIC ACID, ... Authors: Wang, Y, Hao, Q. Deposit date: 2017-01-13 Release date: 2018-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: The Yaf9 YEATS domain Recognizing H3K122suc Peptide To Be Published
5XNV	Crystal structure of YEATS2 YEATS bound to H3K27ac peptide Descriptor: ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, CHLORIDE ION, ... Authors: Li, H.T, Guan, H.P, Zhao, D. Deposit date: 2017-05-24 Release date: 2017-11-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.696 Å) Cite: YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun, 8, 2017
5VNB	YEATS in complex with histone H3 Descriptor: 1,2-ETHANEDIOL, H3K23acK27ac peptide, SULFATE ION, ... Authors: Cho, H.J, Cierpicki, T. Deposit date: 2017-04-29 Release date: 2018-09-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS Chem. Biol., 13, 2018
5YYF	Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group Descriptor: 2-FUROIC ACID, Peptide inhibitor PHQ-H3(Q5-K9), Protein AF-9, ... Authors: Li, Y, Li, H. Deposit date: 2017-12-09 Release date: 2018-11-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.903 Å) Cite: Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking. Nat. Chem. Biol., 14, 2018
6HT1	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with SGC-iMLLT (compound 92) Descriptor: 1,2-ETHANEDIOL, 1-methyl-~{N}-[2-[[(2~{S})-2-methylpyrrolidin-1-yl]methyl]-3~{H}-benzimidazol-5-yl]indazole-5-carboxamide, Protein ENL, ... Authors: Heidenreich, D, Chaikuad, A, Moustakim, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-10-02 Release date: 2018-10-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew. Chem. Int. Ed. Engl., 57, 2018
6HPY	Crystal structure of ENL (MLLT1) in complex with compound 12 Descriptor: 1,2-ETHANEDIOL, 3-[4-[(4-~{tert}-butylphenyl)carbonylamino]phenyl]propanoic acid, Protein ENL, ... Authors: Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-09-22 Release date: 2018-11-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HPX	Crystal structure of ENL (MLLT1) in complex with compound 19 Descriptor: 1,2-ETHANEDIOL, Protein ENL, ~{N}-[(3-chlorophenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole-5-carboxamide Authors: Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-09-22 Release date: 2018-11-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HPZ	Crystal structure of ENL (MLLT1) in complex with acetyllysine Descriptor: 1,2-ETHANEDIOL, N(6)-ACETYLLYSINE, Protein ENL Authors: Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-09-22 Release date: 2018-11-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HPW	Crystal structure of ENL (MLLT1) in complex with compound 20 Descriptor: 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, Protein ENL Authors: Heidenreich, D, Chaikuad, A, Moustakim, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-09-22 Release date: 2018-11-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HQ0	Crystal structure of ENL (MLLT1), apo form Descriptor: 1,2-ETHANEDIOL, Protein ENL Authors: Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-09-22 Release date: 2018-11-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HT0	Crystal structure of MLLT1 (ENL) YEATS domain in complexed with compound 94 Descriptor: 1,2-ETHANEDIOL, 1-cyclopropyl-~{N}-[2-[[(2~{S})-2-methylpyrrolidin-1-yl]methyl]-3~{H}-benzimidazol-5-yl]indazole-5-carboxamide, Protein ENL, ... Authors: Heidenreich, D, Chaikuad, A, Moustakim, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-10-02 Release date: 2018-10-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew. Chem. Int. Ed. Engl., 57, 2018

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