PDB: 281 件ウェブページステータス検索Chemie searchBIRD

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2VKZ	Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex 分子名称: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, FATTY ACID SYNTHASE SUBUNIT ALPHA, ... 著者 Johansson, P, Wiltschi, B, Kumari, P, Kessler, B, Vonrhein, C, Vonck, J, Oesterhelt, D, Grininger, M. 登録日 2008-01-07 公開日 2008-08-12 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex. Proc.Natl.Acad.Sci.USA, 105, 2008
2VB7	beta-ketoacyl-ACP synthase I (KAS) from E. coli, apo structure after soak in PEG solution 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2UV8	Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom resolution 分子名称: FATTY ACID SYNTHASE SUBUNIT ALPHA (FAS2), FATTY ACID SYNTHASE SUBUNIT BETA (FAS1), FLAVIN MONONUCLEOTIDE 著者 Leibundgut, M, Jenni, S, Frick, C, Ban, N. 登録日 2007-03-09 公開日 2007-04-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase Science, 316, 2007
2VB8	beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, CHLORIDE ION, THIOLACTOMYCIN 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2VB9	beta-ketoacyl-ACP synthase I (KAS) from E. coli, apo structure 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, CHLORIDE ION 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2VZ8	Crystal Structure of Mammalian Fatty Acid Synthase 分子名称: FATTY ACID SYNTHASE 著者 Maier, T, Leibundgut, M, Ban, N. 登録日 2008-07-31 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.219 Å) 主引用文献 The Crystal Structure of a Mammalian Fatty Acid Synthase. Science, 321, 2008
2VZ9	Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP 分子名称: FATTY ACID SYNTHASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Maier, T, Leibundgut, M, Ban, N. 登録日 2008-07-31 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The Crystal Structure of a Mammalian Fatty Acid Synthase. Science, 321, 2008
2WGF	Crystal structure of Mycobacterium tuberculosis C171Q KasA variant 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
4LS8	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a covalent complex with cerulenin 分子名称: (3R,7E,10E)-3-hydroxy-4-oxododeca-7,10-dienamide, 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2014-06-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
2WGD	Crystal structure of KasA of Mycobacterium tuberculosis 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGE	Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
4LS6	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) I108F mutant from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
2WGG	Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, NONAETHYLENE GLYCOL, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
4LS7	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a non-covalent complex with cerulenin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Cerulenin, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.674 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS5	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, GLYCEROL, POTASSIUM ION 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4NA2	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate 分子名称: Polyketide synthase PksJ 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4MZ0	Structure of a ketosynthase-acyltransferase di-domain from module CurL of the curacin A polyketide synthase 分子名称: CALCIUM ION, CurL 著者 Whicher, J.R, Smaga, S.S, Smith, J.L. 登録日 2013-09-28 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem.Biol., 20, 2013
4NA1	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4NA3	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4OPF	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS8 分子名称: NRPS/PKS 著者 Osipiuk, J, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-05 公開日 2014-02-19 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4OQJ	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmQ KS1 分子名称: GLYCEROL, PHOSPHATE ION, PKS, ... 著者 Nocek, B, Mack, J, Endras, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-09 公開日 2014-03-19 最終更新日 2016-11-02 実験手法 X-RAY DIFFRACTION (1.904 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4OPE	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS7 分子名称: NITRATE ION, NRPS/PKS 著者 Osipiuk, J, Mack, J, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-05 公開日 2014-02-19 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
2AQ7	Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli 分子名称: (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
2AQB	Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli 分子名称: (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
2ALM	Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae 分子名称: 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION 著者 Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O. 登録日 2005-08-07 公開日 2005-08-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. J.Biol.Chem., 281, 2006

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