2VKZ

Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex

Summary for 2VKZ

Related2UV8
DescriptorFATTY ACID SYNTHASE SUBUNIT ALPHA, FATTY ACID SYNTHASE SUBUNIT BETA, (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, ... (4 entities in total)
Functional Keywordstransferase, phosphorylation, phosphopantetheine, fatty acid synthase, multifunctional enzyme, oxidoreductase, lipid synthesis, fas, nad, nadp, lyase, cerulenin, hydrolase, fatty acid biosynthesis
Biological sourceSACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Total number of polymer chains6
Total molecular weight1310419.27
Authors
Johansson, P.,Wiltschi, B.,Kumari, P.,Kessler, B.,Vonrhein, C.,Vonck, J.,Oesterhelt, D.,Grininger, M. (deposition date: 2008-01-07, release date: 2008-08-12, Last modification date: 2017-06-21)
Primary citation
Johansson, P.,Wiltschi, B.,Kumari, P.,Kessler, B.,Vonrhein, C.,Vonck, J.,Oesterhelt, D.,Grininger, M.
Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex.
Proc.Natl.Acad.Sci.USA, 105:12803-, 2008
PubMed: 18725634 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0805827105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278271.1%11.1%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution