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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2VKZ

Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0004321molecular_functionfatty-acyl-CoA synthase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005835cellular_componentfatty acid synthase complex
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
B0000287molecular_functionmagnesium ion binding
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0004321molecular_functionfatty-acyl-CoA synthase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005835cellular_componentfatty acid synthase complex
B0006633biological_processfatty acid biosynthetic process
B0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
B0016746molecular_functionacyltransferase activity
B0042759biological_processlong-chain fatty acid biosynthetic process
C0000287molecular_functionmagnesium ion binding
C0004312molecular_functionfatty acid synthase activity
C0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
C0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C0004321molecular_functionfatty-acyl-CoA synthase activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005835cellular_componentfatty acid synthase complex
C0006633biological_processfatty acid biosynthetic process
C0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
C0016746molecular_functionacyltransferase activity
C0042759biological_processlong-chain fatty acid biosynthetic process
G0004312molecular_functionfatty acid synthase activity
G0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
G0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
G0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
G0004321molecular_functionfatty-acyl-CoA synthase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0005835cellular_componentfatty acid synthase complex
G0006633biological_processfatty acid biosynthetic process
G0016297molecular_functionfatty acyl-[ACP] hydrolase activity
G0016409molecular_functionpalmitoyltransferase activity
G0016740molecular_functiontransferase activity
G0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
G0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G0042759biological_processlong-chain fatty acid biosynthetic process
G0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
H0004312molecular_functionfatty acid synthase activity
H0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
H0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
H0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
H0004321molecular_functionfatty-acyl-CoA synthase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005811cellular_componentlipid droplet
H0005829cellular_componentcytosol
H0005835cellular_componentfatty acid synthase complex
H0006633biological_processfatty acid biosynthetic process
H0016297molecular_functionfatty acyl-[ACP] hydrolase activity
H0016409molecular_functionpalmitoyltransferase activity
H0016740molecular_functiontransferase activity
H0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
H0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H0042759biological_processlong-chain fatty acid biosynthetic process
H0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
I0004312molecular_functionfatty acid synthase activity
I0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
I0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
I0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
I0004321molecular_functionfatty-acyl-CoA synthase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005811cellular_componentlipid droplet
I0005829cellular_componentcytosol
I0005835cellular_componentfatty acid synthase complex
I0006633biological_processfatty acid biosynthetic process
I0016297molecular_functionfatty acyl-[ACP] hydrolase activity
I0016409molecular_functionpalmitoyltransferase activity
I0016740molecular_functiontransferase activity
I0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
I0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I0042759biological_processlong-chain fatty acid biosynthetic process
I0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE FMN G3051
ChainResidue
GPRO595
GGLY737
GGLY738
GSER769
GGLY770
GGLY802
GSER803
GMET806
GLEU1054
GALA1059
GGLY596
GMET597
GTHR598
GPRO599
GASN650
GGLY682
GLYS706
GTHR733
site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE FMN H3051
ChainResidue
HPRO595
HGLY596
HMET597
HTHR598
HPRO599
HASN650
HILE652
HGLY682
HLYS706
HTHR733
HGLY737
HGLY738
HSER769
HGLY770
HGLY802
HSER803
HLEU1054
HALA1059
site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE FMN I3051
ChainResidue
IPRO595
IGLY596
IMET597
ITHR598
IASN650
IILE652
IGLY682
ILYS706
ITHR733
IGLY737
IGLY738
IGLY739
ISER769
IGLY770
IGLY802
ISER803
ILEU1054
IALA1059
site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE CER A2748
ChainResidue
APHE1279
AALA1304
ACYS1305
APHE1343
AHIS1542
AHIS1583
ALYS1585
APHE1644
APHE1646
site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CER B2748
ChainResidue
BCYS1305
BPHE1343
BHIS1542
BHIS1583
BLYS1585
BPHE1644
BPHE1646
CPHE1279
site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE CER C2748
ChainResidue
BPHE1279
CALA1304
CCYS1305
CPHE1343
CHIS1542
CHIS1583
CLYS1585
CPHE1644
CPHE1646
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL
ChainResidueDetails
ALEU175-LEU190
site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV
ChainResidueDetails
AGLY1296-VAL1312
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues225
DetailsDomain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1602
DetailsDomain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues597
DetailsRegion: {"description":"Beta-ketoacyl reductase"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsActive site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17431182","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues375
DetailsDomain: {"description":"MaoC-like"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1164
DetailsRegion: {"description":"Enoyl reductase"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1446
DetailsRegion: {"description":"Dehydratase"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues654
DetailsRegion: {"description":"Malonyl/palmitoyl transferase"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsActive site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsActive site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
GILE1579
GGLY1582
GASP1559
GHIS1564
site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
HILE1579
HGLY1582
HASP1559
HHIS1564
site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
IILE1579
IGLY1582
IASP1559
IHIS1564
site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
AASP836
ALYS843
site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BASP836
BLYS843
site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CASP836
CLYS843
site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
ATYR839
ALYS843
site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BTYR839
BLYS843
site_idCSA9
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CTYR839
CLYS843

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PDB entries from 2026-04-01

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