PDB: 164 resultsInfo pagesStatus searchChemie searchBIRD

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8IQK	Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins Descriptor: Bcl-2-like protein 1, Bcl-2-modifying factor Authors: Wang, H, Guo, M, Wei, H, Chen, Y. Deposit date: 2023-03-16 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (2.879 Å) Cite: Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins. Comput Struct Biotechnol J, 21, 2023
2LP8	SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL Descriptor: 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 Authors: Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. Deposit date: 2012-02-03 Release date: 2012-04-18 Last modified: 2021-08-18 Method: SOLUTION NMR Cite: NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
2LPC	NMR STRUCTURE of Bcl-XL Descriptor: Bcl-2-like protein 1 Authors: Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. Deposit date: 2012-02-09 Release date: 2012-03-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
2ME9	Solution structure of BCL-xL containing the alpha1-alpha2 disordered loop determined with selective isotope labelling of I,L,V sidechains Descriptor: Bcl-2-like protein 1 Authors: Viacava Follis, A, Grace, C.R, Kriwacki, R.W. Deposit date: 2013-09-25 Release date: 2014-04-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat.Struct.Mol.Biol., 21, 2014
2ME8	Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains Descriptor: Bcl-2-like protein 1 Authors: Viacava Follis, A, Grace, C.R, Kriwacki, R.W. Deposit date: 2013-09-25 Release date: 2014-04-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat.Struct.Mol.Biol., 21, 2014
2M04	Solution structure of BCL-xL in complex with PUMA BH3 peptide Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1 Authors: Viacava Follis, A, Royappa, G, Kriwacki, R.W. Deposit date: 2012-10-19 Release date: 2013-01-30 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2MEJ	Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints Descriptor: Bcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION Authors: Viacava Follis, A, Grace, C.R, Kriwacki, R.W. Deposit date: 2013-09-25 Release date: 2014-04-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat.Struct.Mol.Biol., 21, 2014
2M03	Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains Descriptor: Bcl-2-like protein 1 Authors: Viacava Follis, A, Royappa, G, Kriwacki, R.W. Deposit date: 2012-10-19 Release date: 2013-01-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2O2M	Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand Descriptor: 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE, Apoptosis regulator Bcl-X Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-30 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
2O22	Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand Descriptor: Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
2O1Y	Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand Descriptor: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-X Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
2O2N	Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand Descriptor: 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE, Apoptosis regulator Bcl-X Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-30 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
2O2F	Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand Descriptor: 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE, Apoptosis regulator Bcl-2 Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007
2O21	Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand Descriptor: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-2 Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007

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