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3HQJ
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Structure-function analysis of Mycobacterium tuberculosis acyl carrier protein synthase (AcpS).
分子名称: COENZYME A, Holo-[acyl-carrier-protein] synthase, MAGNESIUM ION
著者Dym, O, Albeck, S, Peleg, Y, Schwarz, A, Shakked, Z, Burstein, Y, Zimhony, O, Israel Structural Proteomics Center (ISPC)
登録日2009-06-07
公開日2009-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
J.Mol.Biol., 393, 2009
1F7L
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HOLO-(ACYL CARRIER PROTEIN) SYNTHASE IN COMPLEX WITH COENZYME A AT 1.5A
分子名称: CALCIUM ION, CHLORIDE ION, COENZYME A, ...
著者Parris, K.D, Lin, L, Tam, A, Mathew, R, Hixon, J, Stahl, M, Fritz, C.C, Seehra, J, Somers, W.S.
登録日2000-06-27
公開日2001-06-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8, 2000
1F7T
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HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, GLYCEROL, ...
著者Parris, K.D, Lin, L, Tam, A, Mathew, R, Hixon, J, Stahl, M, Fritz, C.C, Seehra, J, Somers, W.S.
登録日2000-06-27
公開日2001-06-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8, 2000
1FTE
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BU of 1fte by Molmil
CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE ACYL CARRIER PROTEIN SYNTHASE (NATIVE 1)
分子名称: ACYL CARRIER PROTEIN SYNTHASE, SULFATE ION
著者Chirgadze, N, Briggs, S, McAllister, K, Fischl, A, Zhao, G.
登録日2000-09-12
公開日2001-09-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis.
EMBO J., 19, 2000
1FTH
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE ACYL CARRIER PROTEIN SYNTHASE (3'5'-ADP COMPLEX)
分子名称: ACYL CARRIER PROTEIN SYNTHASE, ADENOSINE-3'-5'-DIPHOSPHATE
著者Chirgadze, N, Briggs, S, McAllister, K, Fischl, A, Zhao, G.
登録日2000-09-12
公開日2001-09-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis.
EMBO J., 19, 2000
1FTF
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE ACYL CARRIER PROTEIN SYNTHASE (NATIVE 2)
分子名称: ACYL CARRIER PROTEIN SYNTHASE
著者Chirgadze, N, Briggs, S, McAllister, K, Fischl, A, Zhao, G.
登録日2000-09-12
公開日2001-09-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis.
EMBO J., 19, 2000
2QG8
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Plasmodium yoelii acyl carrier protein synthase PY06285 with ADP bound
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Acyl Carrier Protein Synthase PY06285, MAGNESIUM ION
著者Lunin, V.V, Wernimont, A.K, Lew, J, Wasney, G, Kozieradzki, I, Vedadi, M, Bochkarev, A, Arrowsmith, C.H, Sundstrom, M, Weigelt, J, Edwards, A.E, Hui, R, Brokx, S, Altamentova, S, Structural Genomics Consortium (SGC)
登録日2007-06-28
公開日2007-07-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Plasmodium yoelii acyl carrier protein synthase PY06285 with ADP bound
TO BE PUBLISHED
2WDS
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Crystal structure of the Streptomyces coelicolor H110A AcpS mutant in complex with cofactor CoA at 1.3 A
分子名称: COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION
著者Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T.
登録日2009-03-26
公開日2010-04-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WAS
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BU of 2was by Molmil
Structure of the fungal type I FAS PPT domain
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE
著者Johansson, P, Mulincacci, B, Koestler, C, Grininger, M.
登録日2009-02-15
公開日2009-08-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Multimeric Options for the Auto-Activation of the Saccharomyces Cerevisiae Fas Type I Megasynthase.
Structure, 17, 2009
2WDY
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BU of 2wdy by Molmil
Crystal structure of the Streptomyces coelicolor D111A AcpS mutant in complex with cofactor CoA at 1.4 A
分子名称: COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ...
著者Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T.
登録日2009-03-27
公開日2010-04-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WDO
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BU of 2wdo by Molmil
Crystal structure of the S. coelicolor AcpS in complex with acetyl- CoA at 1.5 A
分子名称: ACETYL COENZYME *A, COENZYME A, GLYCEROL, ...
著者Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T.
登録日2009-03-25
公開日2010-04-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WAT
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BU of 2wat by Molmil
Structure of the fungal type I FAS PPT domain in complex with CoA
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, CHLORIDE ION, COENZYME A, ...
著者Johansson, P, Mulincacci, B, Koestler, C, Grininger, M.
登録日2009-02-15
公開日2009-08-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Multimeric Options for the Auto-Activation of the Saccharomyces Cerevisiae Fas Type I Megasynthase.
Structure, 17, 2009
4U89
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BU of 4u89 by Molmil
4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
分子名称: COENZYME A, IMIDAZOLE, PHOSPHATE ION, ...
著者Faille, A, Mourey, L, Pedelacq, J.D.
登録日2014-08-01
公開日2015-08-26
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献X-ray structure of the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
to be published
8GKF
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Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
分子名称: 4'-phosphopantetheinyl transferase PptT, TOMUDEX
著者Krieger, I.V, Singh, A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2023-03-18
公開日2024-03-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv, 10, 2024
7ED1
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BU of 7ed1 by Molmil
Transferase from Mycobacterium tuberculosis
分子名称: 4'-phosphopantetheinyl transferase, CALCIUM ION, COENZYME A, ...
著者Kim, D.-G, Lee, B.-J, Lee, S.J.
登録日2021-03-15
公開日2022-03-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Transferase from Mycobacterium tuberculosis
To Be Published
7ED0
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BU of 7ed0 by Molmil
Transferase from Mycobacterium tuberculosis
分子名称: 4'-phosphopantetheinyl transferase superfamily protein, COENZYME A, SULFATE ION
著者Kim, D.-G, Lee, B.-J, Lee, S.J.
登録日2021-03-15
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Transferase from Mycobacterium tuberculosis
To Be Published
7ED2
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BU of 7ed2 by Molmil
Transferase from Mycobacterium tuberculosis
分子名称: 4'-phosphopantetheinyl transferase, ADENOSINE-3'-5'-DIPHOSPHATE, MAGNESIUM ION
著者Kim, D.-G, Lee, B.-J, Lee, S.J.
登録日2021-03-15
公開日2022-03-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Transferase from Mycobacterium tuberculosis
To Be Published
7N8M
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BU of 7n8m by Molmil
PptT PAP(CoA) 8978B complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-15
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8L
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PptT PAP(CoA) 9016 complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-15
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8E
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BU of 7n8e by Molmil
PptT PAP(CoA) 9056 complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-14
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
4QJK
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BU of 4qjk by Molmil
Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT
分子名称: COENZYME A, Phosphopantetheinyl transferase PptT, SULFATE ION
著者Noel, J.P, Burkart, M.D, Vickery, C.R.
登録日2014-06-04
公開日2014-07-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
4QJL
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BU of 4qjl by Molmil
Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT
分子名称: COENZYME A, MAGNESIUM ION, Phosphopantetheinyl transferase, ...
著者Noel, J.P, Burkart, M.D, Vickery, C.R.
登録日2014-06-04
公開日2014-07-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
7B4R
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BU of 7b4r by Molmil
Structure of the 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus in complex with Coenzyme A and N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea
分子名称: COENZYME A, MANGANESE (II) ION, N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea, ...
著者Maveyraud, L, Carivenc, C, Blanger, C, Mourey, L.
登録日2020-12-02
公開日2021-11-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Sci Rep, 11, 2021
7B4S
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BU of 7b4s by Molmil
Structure of the 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus in complex with Coenzyme A and compound 153786 from the NCI Open Database
分子名称: 5-[(4-chlorophenyl)methyl]-6-[[2-(dimethylamino)ethylamino]methyl]-4-oxidanyl-1~{H}-pyrimidine-2-thione, COENZYME A, MANGANESE (II) ION, ...
著者Maveyraud, L, Carivenc, C, Mourey, L.
登録日2020-12-02
公開日2021-11-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Sci Rep, 11, 2021
7BCZ
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Structure of the 4'-phosphopantetheinyl transferase PcpS from Pseudomonas aeruginosa
分子名称: 4'-phosphopantetheinyl transferase EntD, COENZYME A, MAGNESIUM ION, ...
著者Carivenc, C, Mourey, L, Pedelacq, J.D.
登録日2020-12-21
公開日2021-11-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Sci Rep, 11, 2021

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