PDB: 149 resultsInfo pagesStatus searchChemie searchBIRD

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2GDG	Crystal structure of covalently modified macrophage inhibitory factor Descriptor: Macrophage migration inhibitory factor Authors: Golubkov, P.A, Hackert, M.L. Deposit date: 2006-03-16 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate. Bioorg.Chem., 34, 2006
5V73	Crystal structure of N110A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-03-17 Release date: 2018-03-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Crystal structure of N110A mutant of human macrophage migration inhibitory factor To Be Published
6CUQ	Crystal structure of Macrophage migration inhibitory factor-like protein (EhMIF) from Entamoeba histolytica Descriptor: 1,2-ETHANEDIOL, Macrophage migration inhibitory factor-like protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-03-26 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structure of Macrophage migration inhibitory factor-like protein (EhMIF) from Entamoeba histolytica to be published
4NWR	Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28 Descriptor: Macrophage migration inhibitory factor-like protein, integron gene cassette protein Authors: McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. Deposit date: 2013-12-06 Release date: 2014-05-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
3CE4	Structure of Macrophage Migration Inhibitory Factor Covalently Inhibited by PMSF Treatment Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Crichlow, G.V, Lolis, E. Deposit date: 2008-02-28 Release date: 2008-12-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry, 48, 2009
5XEJ	Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX Descriptor: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Takimoto-Kamimura, M, Fukushima, K. Deposit date: 2017-04-05 Release date: 2018-07-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of macrophage migration inhibitory factor in complex with methotrexate. Acta Crystallogr D Struct Biol, 77, 2021
8AP3	Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) Descriptor: MIF homologue Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-08-09 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) To Be Published
3L5T	Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution Descriptor: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
6ICE	Crystal structure of Hamster MIF Descriptor: Macrophage migration inhibitory factor Authors: Sundaram, R, Vasudevan, D. Deposit date: 2018-09-05 Release date: 2019-09-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer. Sci Rep, 9, 2019
7KQX	MIF Y99C homotrimeric mutant Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Manjula, R, Georgios, P, Lolis, E.J. Deposit date: 2020-11-18 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Front Mol Biosci, 9, 2022
2WKF	Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum Descriptor: GLYCEROL, MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Dobson, S.E, Augustijn, K.D, Brannigan, J.A, Dodson, E.J, Waters, A.P, Wilkinson, A.J. Deposit date: 2009-06-11 Release date: 2009-10-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei. Protein Sci., 18, 2009
5EIZ	Crystal structure of Y99A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-10-30 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 2018
8UR2	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I41 form) Descriptor: IODIDE ION, MACROPHAGE MIGRATION INHIBITORY FACTOR, PYRUVIC ACID Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-10-25 Release date: 2023-11-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I41 form) To be published
8IMR	Structure of ligand-free human macrophage migration inhibitory factor Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. Deposit date: 2023-03-07 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis To Be Published
4DH4	Macrophage migration inhibitory factor Toxoplasma gondii Descriptor: MIF, SULFATE ION Authors: Richardson, J.M. Deposit date: 2012-01-27 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor. J.Biol.Chem., 288, 2013
4K9G	1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound Descriptor: (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, CHLORIDE ION, ... Authors: Crichlow, G.V, Al-Abed, Y, Lolis, E.J. Deposit date: 2013-04-19 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45, 2014
1UIZ	Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis. Descriptor: Macrophage Migration Inhibitory Factor Authors: Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T. Deposit date: 2003-07-24 Release date: 2004-05-25 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development. J.Biol.Chem., 279, 2004
8DQA	Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) Descriptor: LS1-like protein Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) To Be Published
3T5S	Structure of macrophage migration inhibitory factor from Giardia lamblia Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-07-28 Release date: 2011-08-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. J.Struct.Funct.Genom., 14, 2013
8DQ6	Structure of A. thaliana MIF/D-DT-like protein-1 (MDL1) Descriptor: CALCIUM ION, MIF/D-DT-like protein-1 Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-1 (AtMDL1) To Be Published
7XTX	High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. Deposit date: 2022-05-18 Release date: 2023-05-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis To Be Published
7XVX	Neutron crystal structure of human macrophage migration inhibitory factor Descriptor: Macrophage migration inhibitory factor Authors: Ezawa, T, Tamada, T, Odaka, M, Matsumura, H. Deposit date: 2022-05-25 Release date: 2023-05-31 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION Cite: Neutron crystal structure of human macrophage migration inhibitory factor To Be Published
3U18	Chicago Sky Blue 6B, A Novel Inhibitor for Macrophage Migration Inhibitory Factor Descriptor: 1,2-ETHANEDIOL, 6,6'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis(4-amino-5-hydroxynaphthalene-1,3-disulfonic acid), GLYCEROL, ... Authors: Asojo, O.A. Deposit date: 2011-09-29 Release date: 2012-07-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF). J.Biol.Chem., 287, 2012
1HFO	The Structure of the Macrophage Migration Inhibitory Factor from Trichinella Spiralis. Descriptor: MIGRATION INHIBITORY FACTOR Authors: Roe, S.M, Meyer, D.J. Deposit date: 2000-12-07 Release date: 2001-08-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Macrophage Migration Inhibitory Factor of the Parasitic Nematode Trichinella Spiralis Biochem.J., 357, 2001
8CA0	Macrophage inhibitory factor (MIF) in complex with small molecule PAV174 Descriptor: 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine, Macrophage migration inhibitory factor Authors: Mueller, A, Torres, F, Roland, R, Korth, C. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: SOLUTION NMR Cite: Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology To Be Published

 

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