2HRM
 
 | | Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, Deoxyuridine 5'-triphosphate nucleotidohydrolase | | Authors: | Barabas, O, Kovari, J, Tapai, R, Vertessy, B.G. | | Deposit date: | 2006-07-20 | | Release date: | 2007-07-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71, 2008
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2HXD
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1VYQ
 | | Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design | | Descriptor: | 2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE | | Authors: | Whittingham, J.L, Leal, I, Kasinathan, G, Nguyen, C, Bell, E, Jones, A.F, Berry, C, Benito, A, Turkenburg, J.P, Dodson, E.J, Ruiz Perez, L.M, Wilkinson, A.J, Johansson, N.G, Brun, R, Gilbert, I.H, Gonzalez Pacanowska, D, Wilson, K.S. | | Deposit date: | 2004-05-05 | | Release date: | 2005-05-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Dutpase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors.
Structure, 13, 2005
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2J4H
 | | Crystal structure of a H121A Escherichia coli dCTP deaminase mutant enzyme | | Descriptor: | DEOXYCYTIDINE DIPHOSPHATE, DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, MAGNESIUM ION | | Authors: | Johansson, E, Thymark, M, Bynck, J.H, Fanoe, M, Larsen, S, Willemoes, M. | | Deposit date: | 2006-08-31 | | Release date: | 2007-08-07 | | Last modified: | 2019-03-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
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2J4Q
 | | Crystal structure of a E138A Escherichia coli dCTP deaminase mutant enzyme in complex with dTTP | | Descriptor: | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ... | | Authors: | Johansson, E, Thymark, M, Bynck, J.H, Fanoe, M, Larsen, S, Willemoes, M. | | Deposit date: | 2006-09-05 | | Release date: | 2007-08-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
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1XS4
 | | dCTP deaminase from Escherichia coli- E138A mutant enzyme in complex with dCTP | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION | | Authors: | Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M. | | Deposit date: | 2004-10-18 | | Release date: | 2004-12-21 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
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1XS1
 | | dCTP deaminase from Escherichia coli in complex with dUTP | | Descriptor: | DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION | | Authors: | Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M. | | Deposit date: | 2004-10-18 | | Release date: | 2004-12-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
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1XS6
 | | dCTP deaminase from Escherichia coli. E138A mutant enzyme in complex with dUTP | | Descriptor: | DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION | | Authors: | Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M. | | Deposit date: | 2004-10-18 | | Release date: | 2004-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
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3ARA
 | | Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors | | Descriptor: | 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION | | Authors: | Chong, K.T, Miyakoshi, H, Miyahara, S, Fukuoka, M. | | Deposit date: | 2010-11-25 | | Release date: | 2010-12-08 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors
J.Med.Chem., 55, 2012
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3ARN
 | | Human dUTPase in complex with novel uracil derivative | | Descriptor: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide | | Authors: | Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M. | | Deposit date: | 2010-12-03 | | Release date: | 2010-12-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
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3C3I
 | | Evolution of chlorella virus dUTPase | | Descriptor: | DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine triphosphatase, MAGNESIUM ION | | Authors: | Yamanishi, M, Homma, K, Zhang, Y, Etten, L.V.J, Moriyama, H. | | Deposit date: | 2008-01-28 | | Release date: | 2009-02-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase.
Acta Crystallogr.,Sect.F, 65, 2009
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3C2T
 | | Evolution of chlorella virus dUTPase | | Descriptor: | DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine triphosphatase, MAGNESIUM ION | | Authors: | Yamanishi, M, Homma, K, Zhang, Y, Etten, L.V.J, Moriyama, H. | | Deposit date: | 2008-01-25 | | Release date: | 2009-02-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase.
Acta Crystallogr.,Sect.F, 65, 2009
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3CA9
 | | Evolution of chlorella virus dUTPase | | Descriptor: | DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine triphosphatase, MAGNESIUM ION | | Authors: | Yamanishi, M, Homma, K, Zhang, Y, Etten, L.V.J, Moriyama, H. | | Deposit date: | 2008-02-19 | | Release date: | 2009-03-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase.
Acta Crystallogr.,Sect.F, 65, 2009
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3ECY
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3EHW
 | | Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site | | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION, dUTP pyrophosphatase | | Authors: | Takacs, E, Barabas, O, Vertessy, B.G. | | Deposit date: | 2008-09-15 | | Release date: | 2008-09-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site
To be Published
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3F4F
 | | Crystal structure of dUT1p, a dUTPase from Saccharomyces cerevisiae | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Singer, A.U, Evdokimova, E, Kudritska, M, Edwards, A.M, Yakunin, A.F, Savchenko, A. | | Deposit date: | 2008-10-31 | | Release date: | 2008-11-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.
Biochem.J., 437, 2011
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2OKE
 | | High Resolution Crystal Structures of Vaccinia Virus dUTPase | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Schormann, N, Chattopadhyay, D. | | Deposit date: | 2007-01-16 | | Release date: | 2007-05-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of vaccinia virus dUTPase and its nucleotide complexes.
Acta Crystallogr.,Sect.D, 63, 2007
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2OKD
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2OKB
 | | High Resolution Crystal Structures of Vaccinia Virus dUTPase | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | | Authors: | Schormann, N, Chattopadhyay, D. | | Deposit date: | 2007-01-16 | | Release date: | 2007-05-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structures of vaccinia virus dUTPase and its nucleotide complexes.
Acta Crystallogr.,Sect.D, 63, 2007
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2OL1
 | | High Resolution Crystal Structures of Vaccinia Virus dUTPase | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, ... | | Authors: | Schormann, N, Chattopadhyay, D. | | Deposit date: | 2007-01-18 | | Release date: | 2007-05-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of vaccinia virus dUTPase and its nucleotide complexes.
Acta Crystallogr.,Sect.D, 63, 2007
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2OL0
 | | High Resolution Crystal Structures of Vaccinia Virus dUTPase | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DEOXYURIDINE-5'-DIPHOSPHATE, ... | | Authors: | Schormann, N, Chattopadhyay, D. | | Deposit date: | 2007-01-18 | | Release date: | 2007-05-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of vaccinia virus dUTPase and its nucleotide complexes.
Acta Crystallogr.,Sect.D, 63, 2007
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2PC5
 | | Native crystal structure analysis on Arabidopsis dUTPase | | Descriptor: | DUTP pyrophosphatase-like protein, MAGNESIUM ION | | Authors: | Moriyama, H, Bajaj, M. | | Deposit date: | 2007-03-29 | | Release date: | 2008-02-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Purification, crystallization and preliminary crystallographic analysis of deoxyuridine triphosphate nucleotidohydrolase from Arabidopsis thaliana.
Acta Crystallogr.,Sect.F, 63, 2007
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2PY4
 | | Full length structure of the Mycobacterium tuberculosis dUTPase complexed with magnesium and alpha,beta-imido-dUTP. | | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | | Authors: | Barabas, O, Nagy, N, Takacs, E, Vertessy, B.G. | | Deposit date: | 2007-05-15 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor.
Biochem.Biophys.Res.Commun., 373, 2008
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2QLP
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2QXX
 | | Bifunctional dCTP deaminase: dUTPase from Mycobacterium tuberculosis in complex with dTTP | | Descriptor: | Deoxycytidine triphosphate deaminase, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | | Authors: | Christophersen, S, Harris, P, Willemoes, M. | | Deposit date: | 2007-08-13 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.
J.Mol.Biol., 376, 2008
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