2HRM
Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP
Summary for 2HRM
Entry DOI | 10.2210/pdb2hrm/pdb |
Related | 2HR6 |
Descriptor | Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | jelly roll, enzyme-substrate analogue ligand complex, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 16750.87 |
Authors | Barabas, O.,Kovari, J.,Tapai, R.,Vertessy, B.G. (deposition date: 2006-07-20, release date: 2007-07-31, Last modification date: 2023-08-30) |
Primary citation | Kovari, J.,Barabas, O.,Varga, B.,Bekesi, A.,Tolgyesi, F.,Fidy, J.,Nagy, J.,Vertessy, B.G. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins, 71:308-319, 2008 Cited by PubMed: 17932923DOI: 10.1002/prot.21757 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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