2HRM

Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding
A	0070207	biological_process	protein homotrimerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UC5 A 777

Chain	Residue
A	ARG71
A	MET98
A	HOH778
A	HOH786
A	HOH814
A	HOH820
A	SER72
A	GLY73
A	ASN84
A	GLY87
A	LEU88
A	ILE89
A	ASP90
A	TYR93

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	HIS76
A	GLN106
A	ASP107

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15208312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
A	ASP90
A	ASP92

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 844

Chain	Residue	Details
A	SER28	activator
A	PRO70	electrostatic stabiliser
A	SER72	electrostatic stabiliser
A	GLY79	modifies pKa
A	ILE89	proton acceptor, proton donor

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