6UJP
 
 | | P-glycoprotein mutant-F979A and C952A-with BDE100 | | Descriptor: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1 | | Authors: | Aller, S.G, Le, C.A. | | Deposit date: | 2019-10-03 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.98 Å) | | Cite: | Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
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6UJS
 | | P-glycoprotein mutant-F728A and C952A-with BDE100 | | Descriptor: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1 | | Authors: | Aller, S.G, Le, C.A. | | Deposit date: | 2019-10-03 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.17 Å) | | Cite: | Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
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6UJN
 | | P-glycoprotein mutant-C952A-with BDE100 | | Descriptor: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1 | | Authors: | Aller, S.G, Le, C.A. | | Deposit date: | 2019-10-03 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.98 Å) | | Cite: | Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
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6V9Z
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6UY0
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6UZL
 | | Cryo-EM structure of nucleotide-free MsbA reconstituted into peptidiscs, conformation 2 | | Descriptor: | Lipid A export ATP-binding/permease protein MsbA | | Authors: | Angiulli, G, Walz, T, Dhupar, H.S, Suzuki, H, Wason, I.S, Duong Van Hoa, F. | | Deposit date: | 2019-11-15 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins.
Elife, 9, 2020
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6UZ2
 | | Cryo-EM structure of nucleotide-free MsbA reconstituted into peptidiscs, conformation 1 | | Descriptor: | Lipid A export ATP-binding/permease protein MsbA | | Authors: | Angiulli, G, Walz, T, Dhupar, H.S, Suzuki, H, Wason, I.S, Duong Van Hoa, F. | | Deposit date: | 2019-11-14 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins.
Elife, 9, 2020
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7BG4
 | | Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Lipid A export ATP-binding/permease protein MsbA, MAGNESIUM ION, ... | | Authors: | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | | Deposit date: | 2021-01-05 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
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7BCW
 | | Structure of MsbA in Salipro with ADP vanadate | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent lipid A-core flippase, ... | | Authors: | Traore, D.A.K, Tidow, H. | | Deposit date: | 2020-12-21 | | Release date: | 2022-01-12 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination.
Febs J., 289, 2022
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6VQU
 | | Structure of a bacterial Atm1-family ABC exporter | | Descriptor: | ATM1-type heavy metal exporter | | Authors: | Fan, C, Rees, D.C. | | Deposit date: | 2020-02-05 | | Release date: | 2020-07-29 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VQT
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7D7N
 | | Cryo-EM structure of human ABCB6 transporter | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial | | Authors: | Wang, C, Cao, C, Wang, N, Wang, X, Zhang, X.C. | | Deposit date: | 2020-10-05 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Cryo-electron microscopy structure of human ABCB6 transporter.
Protein Sci., 29, 2020
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7D7R
 | | Cryo-EM structure of the core domain of human ABCB6 transporter | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial | | Authors: | Wang, C, Cao, C, Wang, N, Wang, X, Zhang, X.C. | | Deposit date: | 2020-10-05 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Cryo-electron microscopy structure of human ABCB6 transporter.
Protein Sci., 29, 2020
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7DQV
 | | Crystal structure of a CmABCB1 mutant | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, MAGNESIUM ION, NITRATE ION, ... | | Authors: | Matsuoka, K, Nakatsu, T, Kato, H. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3.
Protein Sci., 30, 2021
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7DNZ
 | | Cryo-EM structure of the human ABCB6 (Hemin and GSH-bound) | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Kim, S, Lee, S.S, Park, J.G, Kim, J.W, Kim, S, Kim, N.J, Hong, S, Kang, J.Y, Jin, M.S. | | Deposit date: | 2020-12-11 | | Release date: | 2022-06-22 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6.
Mol.Cells, 45, 2022
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7DNY
 | | Cryo-EM structure of the human ABCB6 (coproporphyrin III-bound) | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Kim, S, Lee, S.S, Park, J.G, Kim, J.W, Kim, S, Kim, N.J, Hong, S, Kang, J.Y, Jin, M.S. | | Deposit date: | 2020-12-11 | | Release date: | 2022-06-22 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6.
Mol.Cells, 45, 2022
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7EHL
 | | Cryo-EM structure of human ABCB8 transporter in nucleotide binding state | | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Mitochondrial potassium channel ATP-binding subunit, ... | | Authors: | Li, S.J, Yang, X, Shen, Y.Q. | | Deposit date: | 2021-03-29 | | Release date: | 2021-05-05 | | Method: | ELECTRON MICROSCOPY | | Cite: | Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.
Biochem.Biophys.Res.Commun., 557, 2021
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7EKL
 | | Mitochondrial outer membrane protein | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family B member 6, MAGNESIUM ION | | Authors: | Zhang, S.S. | | Deposit date: | 2021-04-05 | | Release date: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular insights into the human ABCB6 transporter.
Cell Discov, 7, 2021
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7EKM
 | | Mitochondrial outer membrane protein | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial | | Authors: | Zhang, S.S. | | Deposit date: | 2021-04-05 | | Release date: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular insights into the human ABCB6 transporter.
Cell Discov, 7, 2021
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7E1A
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7DV5
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8AVY
 | | The ABCB1 L335C mutant (mABCB1) in the Apo state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Parey, K, Januliene, D, Gewering, T, Moeller, A. | | Deposit date: | 2022-08-27 | | Release date: | 2023-09-06 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
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8BJF
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (inward-facing conformation) | | Descriptor: | ATP-binding cassette sub-family C member 4, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-11-04 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BWO
 | | Cryo-EM structure of nanodisc-reconstituted human MRP4 with E1202Q mutation (outward-facing occluded conformation) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BWR
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with prostaglandin E2) | | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, ATP-binding cassette sub-family C member 4 | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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