PDB: 339 件ウェブページステータス検索Chemie searchBIRD

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6X8H	Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct 分子名称: Ac-DW3-KE, Caspase-8 著者 Solania, A, Xu, J.H, Wolan, D.W. 登録日 2020-06-01 公開日 2021-06-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct To Be Published
6X8L	Caspase-7 in complex with elongated ketomethylene inhibitor 分子名称: Caspase-7, ketomethylene inhibitor 著者 Solania, A, Xu, J.H, Wolan, D.W. 登録日 2020-06-01 公開日 2021-06-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Caspase-7 in complex with elongated ketomethylene inhibitor To Be Published
6X8J	Caspase-7 in complex with ketomethylene inhibitor reveals tetrahedral adduct 分子名称: Caspase-7, ketomethylene inhibitor 著者 Solania, A, Xu, J.H, Wolan, D.W. 登録日 2020-06-01 公開日 2021-06-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.604 Å) 主引用文献 Caspase-7 in complex with ketomethylene inhibitor reveals tetrahedral adduct To Be Published
6X8I	Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct 分子名称: Caspase-3, ketomethylene inhibitor 著者 Solania, A, Xu, J.H, Wolan, D.W. 登録日 2020-06-01 公開日 2021-06-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct To Be Published
6X8K	Caspase-3 in complex with elongated ketomethylene inhibitor 分子名称: Caspase-3, ketomethylene inhibitor 著者 Solania, A, Xu, J.H, Wolan, D.W. 登録日 2020-06-01 公開日 2021-06-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Caspase-3 in complex with elongated ketomethylene inhibitor To Be Published
4AFP	The structure of metacaspase 2 from T. brucei determined in the presence of Samarium 分子名称: METACASPASE MCA2, SAMARIUM (III) ION 著者 McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. 登録日 2012-01-23 公開日 2012-05-02 最終更新日 2017-07-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
4ZVU	Caspase-7 wild-type bound to the caspase-6 cognate tetrapeptide inhibitor Ac-VEID-cho 分子名称: Caspase-7, Tetrapeptide Inhibitor Ac-VEID-CHO 著者 Hardy, J.A, MacPherson, D.J, Hill, M.E. 登録日 2015-05-18 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVQ	Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to VEID inhibitor. 分子名称: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASA 著者 Hill, M.E, MacPherson, D.J, Hardy, J.A. 登録日 2015-05-18 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4DCP	Crystal Structure of caspase 3, L168F mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-18 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4ZVS	Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor. 分子名称: Caspase-7, DEVD inhibitor 著者 MacPherson, D.J, Hill, M.E, Hardy, J.A. 登録日 2015-05-18 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVO	Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to VEID inhibitor. 分子名称: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASJ 著者 Hill, M.E, MacPherson, D.J, Hardy, J.A. 登録日 2015-05-18 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4DCJ	Crystal structure of caspase 3, L168D mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-17 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4DCO	Crystal Structure of caspase 3, L168Y mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-18 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4EHA	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.696 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHH	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
1M72	Crystal Structure of Caspase-1 from Spodoptera frugiperda 分子名称: 1,2-ETHANEDIOL, Ace-Asp-Glu-Val-Asp-chloromethylketone, Caspase-1 著者 Forsyth, C.M, Lemongello, D, Friesen, P.D, Fisher, A.J. 登録日 2002-07-18 公開日 2004-01-20 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of an invertebrate caspase. J.Biol.Chem., 279, 2004
6KN1	P20/P12 of caspase-11 mutant C254A 分子名称: Caspase-4 著者 Ding, J, Sun, Q. 登録日 2019-08-02 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6KMT	P32 of caspase-11 mutant C254A 分子名称: Caspase-4 著者 Ding, J, Sun, Q. 登録日 2019-08-01 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6KMU	P22/P10 complex of caspase-11 mutant C254A 分子名称: Caspase-4 著者 Ding, J, Sun, Q. 登録日 2019-08-01 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
1NME	Structure of Casp-3 with tethered salicylate 分子名称: 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID, 3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC ACID, Caspase-3 著者 Erlanson, D.A, Lam, J, Wiesmann, C, Luong, T.N, Simmons, B, DeLano, W, Choong, I.C, Flanagan, M, Lee, D, O'Brian, T. 登録日 2003-01-09 公開日 2003-03-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 In situ assembly of enzyme inhibitors using extended tethering. Nat.Biotechnol., 21, 2003
2XZT	Caspase-3 in Complex with DARPin-3.4_I78S 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, CASPASE-3, DARPIN-3.4_I78S 著者 Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. 登録日 2010-11-29 公開日 2011-12-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Caspase-3 in Complex with Darpin-3.4_I78S To be Published
2XYP	Caspase-3:CAS26049945 分子名称: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE 著者 Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. 登録日 2010-11-18 公開日 2011-08-17 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
2XYG	Caspase-3:CAS329306 分子名称: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide 著者 Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. 登録日 2010-11-17 公開日 2011-08-17 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
2XZD	Caspase-3 in Complex with an Inhibitory DARPin-3.4 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... 著者 Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. 登録日 2010-11-24 公開日 2011-12-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors. Structure, 21, 2013
2Y0B	Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... 著者 Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. 登録日 2010-12-01 公開日 2011-12-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors. Structure, 21, 2013

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