PDB: 165 件ウェブページステータス検索Chemie searchBIRD

---

5M6F	Small Molecule inhibitors of IAP 分子名称: 1-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-2-(methoxymethyl)-5-methyl-piperazin-4-ium-1-yl]ethanone, E3 ubiquitin-protein ligase XIAP, SODIUM ION, ... 著者 Williams, P.A. 登録日 2016-10-25 公開日 2017-05-24 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60, 2017
1XB0	Structure of the BIR domain of IAP-like protein 2 分子名称: Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ... 著者 Shin, H, Renatus, M, Eckelman, B.P, Nunes, V.A, Sampaio, C.A.M, Salvesen, G.S. 登録日 2004-08-27 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition Biochem.J., 385, 2005
1XB1	The Structure of the BIR domain of IAP-like protein 2 分子名称: Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ... 著者 Shin, H, Renatus, M, Eckelman, B.P, Nunes, V.A, Sampaio, C.A.M, Salvesen, G.S. 登録日 2004-08-27 公開日 2004-11-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition Biochem.J., 385, 2005
1XOX	SOLUTION STRUCTURE OF HUMAN SURVIVIN 分子名称: Apoptosis inhibitor survivin, ZINC ION 著者 Sun, C, Nettesheim, D, Liu, Z, Olejniczak, E.T. 登録日 2004-10-07 公開日 2005-01-18 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of human survivin and its binding interface with smac/diablo Biochemistry, 44, 2005
1OY7	Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEVVAVKSE peptide, Baculoviral IAP repeat-containing protein 7, ... 著者 Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. 登録日 2003-04-03 公開日 2003-08-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) Biochemistry, 42, 2003
1OXN	Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEAVPWKSE peptide, Baculoviral IAP repeat-containing protein 7, ... 著者 Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. 登録日 2003-04-03 公開日 2003-08-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) Biochemistry, 42, 2003
1JD4	Crystal Structure of DIAP1-BIR2 分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION 著者 Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. 登録日 2001-06-12 公開日 2001-12-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol.Cell, 8, 2001
1JD6	Crystal Structure of DIAP1-BIR2/Hid Complex 分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION, head involution defective protein 著者 Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. 登録日 2001-06-12 公開日 2001-12-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol.Cell, 8, 2001
1JD5	Crystal Structure of DIAP1-BIR2/GRIM 分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION, cell death protein GRIM 著者 Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. 登録日 2001-06-12 公開日 2001-12-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol.Cell, 8, 2001
1OXQ	Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AVPIAQKSE (Smac) peptide, Baculoviral IAP repeat-containing protein 7, ... 著者 Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. 登録日 2003-04-03 公開日 2003-08-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) Biochemistry, 42, 2003
1Q4Q	Crystal structure of a DIAP1-Dronc complex 分子名称: Apoptosis 1 inhibitor, Nedd2-like caspase CG8091-PA, ZINC ION 著者 Chai, J, Yan, N, Shi, Y. 登録日 2003-08-04 公開日 2003-11-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination Nat.Struct.Biol., 10, 2003
1QBH	SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT 分子名称: INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION 著者 Hinds, M.G, Norton, R.S, Vaux, D.L, Day, C.L. 登録日 1999-04-20 公開日 1999-10-20 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. Nat.Struct.Biol., 6, 1999
1M4M	Mouse Survivin 分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5, ZINC ION 著者 Muchmore, S.W, Chen, J, Jakob, C, Zakula, D, Matayoshi, E.D, Wu, W, Zhang, H, Li, F, Ng, S.C, Altieri, D.C. 登録日 2002-07-03 公開日 2002-09-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN MOL.CELL, 6, 2000
1SE0	Crystal structure of DIAP1 BIR1 bound to a Grim peptide 分子名称: Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION 著者 Yan, N, Wu, J.W, Shi, Y. 登録日 2004-02-15 公開日 2004-04-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat.Struct.Mol.Biol., 11, 2004
1SDZ	Crystal structure of DIAP1 BIR1 bound to a Reaper peptide 分子名称: Apoptosis 1 inhibitor, Reaper, ZINC ION 著者 Yan, N, Wu, J.W, Shi, Y. 登録日 2004-02-15 公開日 2004-04-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat.Struct.Mol.Biol., 11, 2004
4KJU	Crystal structure of XIAP-Bir2 with a bound benzodiazepinone inhibitor. 分子名称: E3 ubiquitin-protein ligase XIAP, N-{(3S)-5-(4-aminobenzoyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N~2~-methyl-L-alaninamide, ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-05-03 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain. J.Med.Chem., 56, 2013
4KMP	Structure of XIAP-BIR3 and inhibitor 分子名称: (2S,2'S)-N,N'-[(6,6'-difluoro-1H,1'H-2,2'-biindole-3,3'-diyl)bis{methanediyl[(2R,4S)-4-hydroxypyrrolidine-2,1-diyl][(2S)-1-oxobutane-1,2-diyl]}]bis[2-(methylamino)propanamide], E3 ubiquitin-protein ligase XIAP, ZINC ION 著者 Li, X, Wang, J, Condon, S.M, Shi, Y. 登録日 2013-05-08 公開日 2014-05-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of XIAP-BIR3 and inhibitor To be Published
4KJV	Crystal structure of XIAP-Bir2 with a bound spirocyclic benzoxazepinone inhibitor. 分子名称: 6-methoxy-5-({(3S)-3-[(N-methyl-L-alanyl)amino]-4-oxo-2',3,3',4,5',6'-hexahydro-5H-spiro[1,5-benzoxazepine-2,4'-pyran]-5-yl}methyl)naphthalene-2-carboxylic acid, E3 ubiquitin-protein ligase XIAP, ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-05-03 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain. J.Med.Chem., 56, 2013
4LGE	Crystal structure of clAP1 BIR3 bound to T3261256 分子名称: (4S,6aR,7aS)-5-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]octahydro-1H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-4-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Dougan, D.R. 登録日 2013-06-27 公開日 2013-08-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. Bioorg.Med.Chem., 21, 2013
4LGU	Crystal structure of clAP1 BIR3 bound to T3226692 分子名称: (3S,8aR)-N-((R)-chroman-4-yl)-2-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Dougan, D.R, Mol, C.D, Snell, G.P. 登録日 2013-06-28 公開日 2013-08-28 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. Bioorg.Med.Chem., 21, 2013
4MTI	Crystal structure of cIAP1 BIR3 bound to T3258042 分子名称: (3S,8aR)-2-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)butanoyl]amino}acetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Snell, G.P, Dougan, D.R. 登録日 2013-09-19 公開日 2013-12-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. Bioorg.Med.Chem., 21, 2013
3CM2	Crystal Structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac010 分子名称: (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(aminomethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION 著者 Cossu, F, Mastrangelo, E, Milani, M. 登録日 2008-03-20 公開日 2008-10-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles. J.Mol.Biol., 384, 2008
3CM7	Crystal Structure of XIAP-BIR3 domain in complex with Smac-mimetic compuond, Smac005 分子名称: (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION 著者 Mastrangelo, E, Cossu, F, Milani, M. 登録日 2008-03-21 公開日 2008-10-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles. J.Mol.Biol., 384, 2008
4MU7	Crystal structure of cIAP1 BIR3 bound to T3450325 分子名称: (3S,10aS)-2-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)butanoyl]amino}acetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indole-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Snell, G.P, Dougan, D.R. 登録日 2013-09-20 公開日 2013-12-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. Bioorg.Med.Chem., 21, 2013
4MTZ	Structure of XIAP-BIR1 in complex with NF023 分子名称: 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid, E3 ubiquitin-protein ligase XIAP, SULFATE ION, ... 著者 Cossu, F, Milani, M, Grassi, S, Mastrangelo, E, Bolognesi, M. 登録日 2013-09-20 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Protein-protein interactions in nfkb pathway: novel tools to promote apoptosis in cancer therapy To be Published

<1234567>