PDB: 40 resultsInfo pagesStatus searchChemie searchBIRD

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6H7E	GEF regulatory domain Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... Authors: Ferrandez, Y, Cherfils, J, Peurois, F. Deposit date: 2018-07-31 Release date: 2020-02-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Membranes prime the RapGEF EPAC1 to transduce cAMP signaling. Nat Commun, 14, 2023
6N9G	Crystal Structure of RGS7-Gbeta5 dimer Descriptor: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 Authors: Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. Deposit date: 2018-12-03 Release date: 2019-01-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.129 Å) Cite: Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex. Elife, 7, 2018
7EWR	Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio Descriptor: Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 Authors: Kim, Y, Jeong, E, Jeong, J, Cho, Y. Deposit date: 2021-05-26 Release date: 2021-12-01 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5. Nat Commun, 12, 2021
7EWP	Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio Descriptor: Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 Authors: Kim, Y, Jeong, E, Jeong, J, Cho, Y. Deposit date: 2021-05-25 Release date: 2021-12-01 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5. Nat Commun, 12, 2021
7SHF	Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex Descriptor: (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ... Authors: Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A. Deposit date: 2021-10-08 Release date: 2021-12-01 Last modified: 2022-01-19 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex. Science, 375, 2022
2BYV	Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state Descriptor: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 Authors: Rehmann, H, Wittinghofer, A, Bos, J.L. Deposit date: 2005-08-08 Release date: 2006-02-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State Nature, 439, 2006
8ADL	Cryo-EM structure of the SEA complex Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... Authors: Tafur, L, Loewith, R. Deposit date: 2022-07-08 Release date: 2022-11-02 Last modified: 2023-05-10 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Cryo-EM structure of the SEA complex. Nature, 611, 2022
8AE6	Cryo-EM structure of the SEA complex wing (SEACIT) Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... Authors: Tafur, L, Loewith, R. Deposit date: 2022-07-12 Release date: 2022-11-02 Last modified: 2023-05-10 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryo-EM structure of the SEA complex. Nature, 611, 2022
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P Descriptor: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... Authors: Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. Deposit date: 2021-06-18 Release date: 2021-09-08 Last modified: 2022-02-23 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (4.24 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE9	cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE8	cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (4.07 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE7	cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-15 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021

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