PDB: 287 resultsInfo pagesStatus searchChemie searchBIRD

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8EIB	Crystal structure of beta-catenin and the MDM2 p53-binding domain in complex with H329, a Helicon Polypeptide Descriptor: Catenin beta-1, E3 ubiquitin-protein ligase Mdm2, H329, ... Authors: Li, K, Travaline, T.L, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. Deposit date: 2022-09-14 Release date: 2023-10-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.76 Å) Cite: Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
8FK3	Adeno-Associated Virus Porcine Origin capsid protein basic regions in complex with Importin-alpha 2 Descriptor: Importin subunit alpha-1, VP1 Authors: Hoad, M, Forwood, J.K, Roby, J.A. Deposit date: 2022-12-20 Release date: 2023-03-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal. Viruses, 15, 2023
8F2Q	Human Parvovirus B19 Nonstructural NS1 Protein NLS bound to Importin Alpha 2 Descriptor: Importin subunit alpha-1, Initiator protein NS1 Authors: Cross, E.M, Forwood, J.K. Deposit date: 2022-11-08 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Importin alpha / beta-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication. Antiviral Res., 213, 2023
8FUC	Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein minor site NLS2 Descriptor: Contaminant peptide KKLARE, Importin subunit alpha-1, Matrix protein Authors: Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. Deposit date: 2023-01-17 Release date: 2023-01-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
8FZK	Dimeric human importin alpha subunit Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Importin subunit alpha-1, MAGNESIUM ION Authors: Donnelly, C.M, Stewart, M, Forwood, J.K. Deposit date: 2023-01-29 Release date: 2023-02-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dimeric human importin alpha subunit To Be Published
8FUA	Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein NLS1 Descriptor: Importin subunit alpha-1, Matrix protein Authors: Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. Deposit date: 2023-01-17 Release date: 2023-02-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
8FZM	Human importin alpha 3 in complex with Bimax2 peptide Descriptor: Bimax2, Importin subunit alpha-3 Authors: Donnelly, C.M, Forwood, J.K. Deposit date: 2023-01-29 Release date: 2023-02-08 Method: X-RAY DIFFRACTION (3 Å) Cite: Human importin alpha 3 in complex with Bimax2 peptide To Be Published
8FUB	Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein NLS1 Descriptor: Importin subunit alpha-3, Matrix protein Authors: Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. Deposit date: 2023-01-17 Release date: 2023-02-15 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
8G4J	Crystal structure of Cavia porcellus (guinea pig) importin-alpha 1 in cargo-free state Descriptor: Importin subunit alpha Authors: Hawker, J.E, Roby, J.A, Stewart, M, Forwood, J.K. Deposit date: 2023-02-09 Release date: 2023-02-22 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of Cavia porcellus (guinea pig) importin-alpha 1 in cargo-free state To Be Published
8GAI	Cavia porcellus (guinea pig) importin-alpha 1 in complex with Bimax2 peptide Descriptor: Bimax2, Importin subunit alpha Authors: Hawker, J.E, Forwood, J.K, Donnelly, C.M, Stewart, M. Deposit date: 2023-02-22 Release date: 2023-04-05 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of Cavia porcellus (guinea pig) importin-alpha 1 in complex with bimax2 peptide To Be Published
8G8Q	RelB NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, bacterial peptide, monopartite p52 NLS Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: p52 monopartite NLS in complex with Importin alpha 2 To Be Published
8G8R	RelB NLS in complex with Importin alpha 2 Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Transcription factor RelB Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: monopartite p52 NLS in complex with Importin alpha 2 To Be Published
8G8S	bipartite p52 NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p100 subunit isoform X1 Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: p52 bipartite NLS in complex with Importin alpha 2 To Be Published
8GCN	CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER Descriptor: Importin subunit alpha-1, Importin subunit beta-1 Authors: Ko, Y, Cingolani, G. Deposit date: 2023-03-02 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER To Be Published
8GSJ	APC-Asef tripeptide inhibitor Descriptor: (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ... Authors: Zhang, J, Wang, X.F, Song, K. Deposit date: 2022-09-06 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: APC-Asef tripeptide inhibitor To Be Published
8HE3	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751) Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1, SULFATE ION Authors: Matsuura, Y. Deposit date: 2022-11-07 Release date: 2023-02-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
8HE0	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type) Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1 Authors: Matsuura, Y. Deposit date: 2022-11-07 Release date: 2023-02-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
8HKW	Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1 Authors: Matsuura, Y. Deposit date: 2022-11-28 Release date: 2022-12-21 Last modified: 2023-03-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data Brief, 47, 2023
7N6G	C1 of central pair Descriptor: CPC1, Calmodulin, DPY30, ... Authors: Han, L, Zhang, K. Deposit date: 2021-06-08 Release date: 2022-05-18 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022
7DVQ	Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... Authors: Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. Deposit date: 2021-01-14 Release date: 2021-03-31 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Structure of the activated human minor spliceosome. Science, 371, 2021
8J07	96nm repeat of human respiratory doublet microtubule and associated axonemal complexes Descriptor: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ... Authors: Gui, M, Brown, A. Deposit date: 2023-04-09 Release date: 2023-07-26 Last modified: 2023-08-02 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
3FEY	Crystal structure of the CBC-importin alpha complex. Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2 Authors: Dias, S.M.G, Ambrosio, A.L.B, Cerione, R.A. Deposit date: 2008-12-01 Release date: 2009-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular basis for the regulation of the cap-binding complex by the importins. Nat.Struct.Mol.Biol., 16, 2009
3FEX	Crystal structure of the CBC-importin alpha complex. Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2 Authors: Dias, S.M.G, Ambrosio, A.L.B, Cerione, R.A. Deposit date: 2008-12-01 Release date: 2009-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.549 Å) Cite: The molecular basis for the regulation of the cap-binding complex by the importins. Nat.Struct.Mol.Biol., 16, 2009
6WX7	SOX2 bound to Importin-alpha 2 Descriptor: Importin subunit alpha-1, Transcription factor SOX-2 Authors: Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. Deposit date: 2020-05-09 Release date: 2020-10-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
6WX8	SOX2 bound to Importin-alpha 3 Descriptor: Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2 Authors: Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. Deposit date: 2020-05-10 Release date: 2020-10-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021

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