6MJL
| Crystal structure of ChREBP NLS peptide bound to importin alpha. | Descriptor: | ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1 | Authors: | Jung, H, Uyeda, K. | Deposit date: | 2018-09-21 | Release date: | 2019-09-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions. Biochem.J., 477, 2020
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4YJE
| Crystal structure of APC-ARM in complexed with Amer1-A1 | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-03 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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4YJL
| Crystal structure of APC-ARM in complexed with Amer1-A2 | Descriptor: | 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-03 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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3AU3
| Crystal structure of armadillo repeat domain of APC | Descriptor: | Adenomatous polyposis coli protein | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-01-28 | Release date: | 2011-11-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68 Structure, 19, 2011
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4YI0
| Structure of mouse importin a1 bound to Pom121NLS | Descriptor: | Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121 | Authors: | Lokareddy, R.K, Cingolani, G. | Deposit date: | 2015-02-27 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane To Be Published
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6N88
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1EE4
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1F59
| IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX | Descriptor: | FXFG NUCLEOPORIN REPEATS, IMPORTIN BETA-1 | Authors: | Bayliss, R, Littlewood, T, Stewart, M. | Deposit date: | 2000-06-13 | Release date: | 2000-08-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. Cell(Cambridge,Mass.), 102, 2000
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4YK6
| Crystal structure of APC-ARM in complexed with Amer1-A4 | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-04 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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6N89
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6K06
| Crystal structure of Importin-alpha and phosphomimetic GM130 | Descriptor: | Importin subunit alpha-1, Peptide from Golgin subfamily A member 2 | Authors: | Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. | Deposit date: | 2019-05-05 | Release date: | 2019-10-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
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5HUY
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4OIH
| Importin Alpha in Complex with the Bipartite NLS of Prp20 | Descriptor: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha-1 | Authors: | Roman, N, Christie, M, Swarbrick, C.M.D, Kobe, B, Forwood, J.K. | Deposit date: | 2014-01-19 | Release date: | 2014-02-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20 Plos One, 8, 2013
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5HUW
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3LWW
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8QXX
| HCMV DNA polymerase processivity factor UL44 phosphorylated NLS 410-433 bound to mouse importin alpha 2 | Descriptor: | DNA polymerase processivity factor, Importin subunit alpha-1 | Authors: | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-10-25 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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8QXW
| HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 | Descriptor: | DNA polymerase processivity factor, Importin subunit alpha-1 | Authors: | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-10-25 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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4PVZ
| Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2 | Descriptor: | Importin subunit alpha, Inner nuclear membrane protein HEH2 | Authors: | Lokareddy, R.K, Hapsari, A.R, van Rheenen, M, Bhardwaj, A, Veenhoff, L.M, Cingolani, C. | Deposit date: | 2014-03-18 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure, 23, 2015
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5IZ8
| Protein-protein interaction | Descriptor: | ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | Deposit date: | 2016-03-25 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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8Q8K
| KI Polyomavirus LTA NLS bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, Large T antigen | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-08-18 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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3NMX
| Crystal structure of APC complexed with Asef | Descriptor: | APC variant protein, Rho guanine nucleotide exchange factor 4 | Authors: | Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. | Deposit date: | 2010-06-22 | Release date: | 2011-07-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
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5IZA
| Protein-protein interaction | Descriptor: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | Deposit date: | 2016-03-25 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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8SV0
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8SG7
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8SUD
| JC Polyomavirus LTA NLS bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, Large T antigen | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-05-12 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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