PDB: 161 resultsInfo pagesStatus searchChemie searchBIRD

---

8T7V	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde) Descriptor: (7M)-7-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-06-21 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T09	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) Descriptor: 6-ethynyl-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-05-31 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8SU8	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). Descriptor: (6P)-6-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Bruystens, J.G.H. Deposit date: 2023-05-11 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8CIT	The FERM domain of human moesin mutant L281R Descriptor: Moesin Authors: Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.536 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIR	The FERM domain of human moesin with a bound peptide identified by phage display Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... Authors: Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIS	The FERM domain of human moesin with two bound peptides identified by phage display Descriptor: 1,2-ETHANEDIOL, ACETATE ION, C3P, ... Authors: Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIU	The FERM domain of human moesin mutant H288A Descriptor: Moesin Authors: Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.393 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8GXE	PTPN21 FERM PTP complex Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 Authors: Chen, L, Zheng, Y.Y, Zhou, C. Deposit date: 2022-09-19 Release date: 2023-09-27 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
8GVL	PTPN21 FERM Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21 Authors: Chen, L, Zheng, Y.Y, Zhou, C. Deposit date: 2022-09-15 Release date: 2023-09-20 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
7EDR	The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin Descriptor: Moesin/ezrin/radixin homolog 2 Authors: Zhang, F, Long, J, Zhou, H. Deposit date: 2021-03-16 Release date: 2021-04-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.527 Å) Cite: The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin. Biochem.Biophys.Res.Commun., 553, 2021
7LWH	Human neurofibromin 2/merlin residues 1-339 in complex with LATS1 Descriptor: GLYCEROL, IMIDAZOLE, Merlin, ... Authors: Primi, M.C, Rangarajan, E.S, Izard, T. Deposit date: 2021-03-01 Release date: 2021-08-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.606 Å) Cite: Conformational flexibility determines the Nf2/merlin tumor suppressor functions. Matrix Biol Plus, 12, 2021
5RYU	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1545196403 Descriptor: 1,2-ETHANEDIOL, 2-fluoro-N-[(1H-pyrazol-3-yl)methyl]aniline, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZ3	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1259341037 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.74 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZI	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z48852953 Descriptor: 1,2-ETHANEDIOL, 4-methyl-N-{[(2R)-oxolan-2-yl]methyl}-1,3-thiazol-2-amine, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.09 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZY	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z219104216 Descriptor: 1,2-ETHANEDIOL, 6-(ethylamino)pyridine-3-carbonitrile, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RYS	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1593306637 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZ4	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434909 Descriptor: (2R)-1-{[(2,6-dichlorophenyl)methyl]amino}propan-2-ol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.61 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZL	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1492796719 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RYR	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z104584152 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.87 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZ0	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z1497321453 Descriptor: (2,5-dimethyl-1,3-thiazol-4-yl)(pyrrolidin-1-yl)methanone, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.74 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZH	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434890 Descriptor: 1,2-ETHANEDIOL, 4-methyl-N-phenylpiperazine-1-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.88 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZV	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z31504642 Descriptor: 1,2-ETHANEDIOL, 2-methoxy-N-phenylacetamide, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RZO	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2856434925 Descriptor: 1,2-ETHANEDIOL, 4-[(5-chloro-1,2,3-thiadiazol-4-yl)methyl]morpholine, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.97 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RYO	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z136583524 Descriptor: 1,2-ETHANEDIOL, 2-methyl-N-(pyridin-4-yl)furan-3-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.58 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published
5RYX	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z2234920345 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Isoform 2 of Band 4.1-like protein 3, ... Authors: Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: EPB41L3 PanDDA analysis group deposition To Be Published

 

1234567>