8CIR

The FERM domain of human moesin with a bound peptide identified by phage display

Summary for 8CIR

Entry DOI	10.2210/pdb8cir/pdb
Descriptor	Moesin, C3P, BROMIDE ION, ... (6 entities in total)
Functional Keywords	pip, ferm domain, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	88122.24
Authors	Bradshaw, W.J.,Katis, V.L.,Leisner, T.M.,Fairhead, M.,Bountra, C.,von Delft, F.,Pearce, K.H.,Brennan, P.E. (deposition date: 2023-02-10, release date: 2023-03-01, Last modification date: 2023-11-29)
Primary citation	Du, Y.,Bradshaw, W.J.,Leisner, T.M.,Annor-Gyamfi, J.K.,Qian, K.,Bashore, F.M.,Sikdar, A.,Nwogbo, F.O.,Ivanov, A.A.,Frye, S.V.,Gileadi, O.,Brennan, P.E.,Levey, A.I.,Axtman, A.D.,Pearce, K.H.,Fu, H.,Katis, V.L. Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299:105382-105382, 2023 Cited by PubMed: 37866628 DOI: 10.1016/j.jbc.2023.105382 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation