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2R42	The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism Descriptor: MAGNESIUM ION, Mevalonate kinase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE Authors: Fu, Z, Voynova, N.E, Miziorko, H.M, Kim, J.P. Deposit date: 2007-08-30 Release date: 2008-06-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism. Biochemistry, 47, 2008
2DEJ	Crystal Structure of galaktokinase from Pyrococcus horikoshii with AMP-PN and galactose Descriptor: Probable galactokinase, alpha-D-galactopyranose, {5'-O-[(R)-{[(S)-AMINO(HYDROXY-KAPPAO)PHOSPHORYL]OXY}(HYDROXY-KAPPAO)PHOSPHORYL]ADENOSINATO(2-)}MAGNESIUM Authors: Inagaki, E, Sakamoto, K, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-02-10 Release date: 2007-05-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of galaktokinase from Pyrococcus horikoshii To be Published
3QT6	Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor DPGP Descriptor: 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, Skaff, A.D, McWhorter, W.J, Miziorko, H.M, Geisbrecht, B.V. Deposit date: 2011-02-22 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.047 Å) Cite: Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. J.Biol.Chem., 286, 2011
3QT8	Crystal structure of mutant S192A Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP Descriptor: (3R)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid, GLYCEROL, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, Skaff, A.D, McWhorter, W.J, Miziorko, H.M, Geisbrecht, B.V. Deposit date: 2011-02-22 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. J.Biol.Chem., 286, 2011
3QT7	Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP Descriptor: (3R)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, Skaff, A.D, McWhorter, W.J, Miziorko, H.M, Geisbrecht, B.V. Deposit date: 2011-02-22 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. J.Biol.Chem., 286, 2011
2GS8	Structure of mevalonate pyrophosphate decarboxylase from Streptococcus pyogenes Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, mevalonate pyrophosphate decarboxylase Authors: Cuff, M.E, Li, H, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2006-04-25 Release date: 2006-06-06 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of mevalonate pyrophosphate decarboxylase from Streptococcus pyogenes To be Published
2HK3	Crystal structure of mevalonate diphosphate decarboxylase from Staphylococcus aureus (orthorhombic form) Descriptor: Diphosphomevalonate decarboxylase Authors: Byres, E, Hunter, W.N. Deposit date: 2006-07-03 Release date: 2007-06-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures of Trypanosoma brucei and Staphylococcus aureus Mevalonate Diphosphate Decarboxylase Inform on the Determinants of Specificity and Reactivity J.Mol.Biol., 371, 2007
2HFU	Crystal structure of L. major mevalonate kinase in complex with R-mevalonate Descriptor: (R)-MEVALONATE, Mevalonate kinase, putative Authors: Sgraja, T, Hunter, W.N. Deposit date: 2006-06-26 Release date: 2007-04-17 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. Bmc Struct.Biol., 7, 2007
2HFS	Crystal structure of L. major mevalonate kinase Descriptor: Mevalonate kinase, putative Authors: Sgraja, T, Hunter, W.N. Deposit date: 2006-06-26 Release date: 2007-04-17 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. Bmc Struct.Biol., 7, 2007
2HKE	Mevalonate diphosphate decarboxylase from Trypanosoma brucei Descriptor: Diphosphomevalonate decarboxylase, putative, SULFATE ION Authors: Byres, E, Alphey, M.S, Hunter, W.N. Deposit date: 2006-07-04 Release date: 2007-06-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Trypanosoma brucei and Staphylococcus aureus Mevalonate Diphosphate Decarboxylase Inform on the Determinants of Specificity and Reactivity J.Mol.Biol., 371, 2007
4DPU	Crystal structure of Staphylococcus epidermidis S192A mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP and ATPgS Descriptor: (3R)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid, Mevalonate diphosphate decarboxylase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-14 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DPX	Crystal structure of S192A Staphylococcus epidermidis mevalonate diphosphate decarboxylase Descriptor: FORMIC ACID, GLYCEROL, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-14 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.948 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DPT	Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP and ATPgS Descriptor: (3R)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid, GLYCEROL, Mevalonate diphosphate decarboxylase, ... Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-14 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.191 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DU8	Crystal structure of Staphylococcus epidermidis D283A mevalonate diphosphate decarboxylase complexed with inhibitor DPGP Descriptor: 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline, GLYCEROL, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-21 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DXL	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abscessus, bound to CMP and ATP Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-02-27 Release date: 2012-03-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4DPW	Crystal structure of Staphylococcus epidermidis D283A mevalonate diphosphate decarboxylase complexed with mevalonate diphosphate and ATPgS Descriptor: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, FORMIC ACID, GLYCEROL, ... Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-14 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.605 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DU7	Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with substrate mevalonate diphosphate Descriptor: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, FORMIC ACID, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-21 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4DPY	Crystal structure of Staphylococcus epidermidis S192A mevalonate diphosphate decarboxylase complexed with inhibitor DPGP Descriptor: 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline, Mevalonate diphosphate decarboxylase Authors: Barta, M.L, McWhorter, W.J, Geisbrecht, B.V. Deposit date: 2012-02-14 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51, 2012
4ED4	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to ATP Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-03-26 Release date: 2012-04-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4EMD	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to CMP and SO4 Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-04-11 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4HAC	Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei Descriptor: MAGNESIUM ION, Mevalonate kinase Authors: Zhuang, N, Lee, K.H. Deposit date: 2012-09-26 Release date: 2012-12-12 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei. Acta Crystallogr.,Sect.F, 68, 2012

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