3QT8

Crystal structure of mutant S192A Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP

Summary for 3QT8

Entry DOI	10.2210/pdb3qt8/pdb
Related	3QT5 3QT6 3QT7
Descriptor	Mevalonate diphosphate decarboxylase, (3R)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	ghmp kinase family, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Staphylococcus epidermidis
Total number of polymer chains	2
Total formula weight	74453.10
Authors	Barta, M.L.,Skaff, A.D.,McWhorter, W.J.,Miziorko, H.M.,Geisbrecht, B.V. (deposition date: 2011-02-22, release date: 2011-05-11, Last modification date: 2023-09-13)
Primary citation	Barta, M.L.,Skaff, D.A.,McWhorter, W.J.,Herdendorf, T.J.,Miziorko, H.M.,Geisbrecht, B.V. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. J.Biol.Chem., 286:23900-23910, 2011 Cited by PubMed: 21561869 DOI: 10.1074/jbc.M111.242016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation