3QT8
Crystal structure of mutant S192A Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FM0 A 328 |
| Chain | Residue |
| A | ALA14 |
| A | ARG193 |
| A | MET196 |
| A | ASP283 |
| A | ALA284 |
| A | HOH362 |
| A | HOH368 |
| A | HOH478 |
| A | TYR18 |
| A | TRP19 |
| A | LYS21 |
| A | ILE27 |
| A | SER139 |
| A | GLY140 |
| A | SER141 |
| A | ARG144 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FM0 B 328 |
| Chain | Residue |
| B | ALA14 |
| B | TYR18 |
| B | TRP19 |
| B | LYS21 |
| B | SER107 |
| B | SER139 |
| B | GLY140 |
| B | SER141 |
| B | ARG144 |
| B | ARG193 |
| B | ASP283 |
| B | ALA284 |
| B | HOH450 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 3968 |
| Chain | Residue |
| A | ILE79 |
| A | ASP82 |
| A | LEU83 |
| A | HOH355 |
| A | HOH482 |
